基于手性MOF与乙炔黑修饰电极对多巴胺和尿酸的同时检测
Simultaneous Detection of Dopamine and Uric Acid Based on Chiral MOF and Acetylene Black Modified Electrode
作者单位E-mail
方智利 华东交通大学材料学院, 南昌 330013 fangzhili1972@126.com 
王平 华东交通大学材料学院, 南昌 330013  
刘胜东 华东交通大学材料学院, 南昌 330013  
王欣 华东交通大学材料学院, 南昌 330013  
聂启祥 华东交通大学材料学院, 南昌 330013  
杨绍明 华东交通大学材料学院, 南昌 330013  
徐文媛 华东交通大学材料学院, 南昌 330013  
周枚花 华东交通大学材料学院, 南昌 330013  
摘要: 采用具有一维手性通道的手性金属有机框架HMOF-Zn与乙炔黑共混复合作为修饰材料改性玻碳电极(HMOF-Zn@AB-Nafion-GCE)。并将复合后的电极对多巴胺(DA)和尿酸(UA)进行同时检测。实验结果表明,HMOF-Zn@AB-Nafion-GCE传感器对UA和DA具有高的灵敏度和良好的选择性,且HMOF-Zn@AB-Nafion-GCE传感器表现出对DA比对UA更高的灵敏度。HMOF-Zn@AB-Nafion-GCE传感器对DA和UA的高灵敏度和高选择性是因为HMOF-Zn有较大的比表面积,同时存在丰富的氢键,在高导电剂乙炔黑的协同作用下能增大电子传递。此外,所制备的传感器在优化条件下对DA和UA均表现出优异的线性响应,DA检测范围为0.15~2.5 μmol·L-1,UA检测范围为0.2~4 μmol·L-1,检出限(S/N=3)分别为0.003和0.02 μmol·L-1,重现性良好。该传感器还成功应用于测定人体尿液中UA和多巴胺盐酸盐注射液中的DA。
关键词: 手性  金属有机骨架配合物  多巴胺  尿酸  电化学
基金项目: 国家自然科学基金(No.21365012)资助项目
Abstract: The chiral metal-organic framework, HMOF-Zn, with a large one-dimensional chiral channel and acetylene black (AB) were chosen as electrode materials to modify glassy carbon electrode (GCE) via a simple electrochemical method, denoted as HMOF-Zn@AB-Nafion-GCE. The HMOF-Zn@AB-Nafion-GCE sensor was used for simultaneous detection of dopamine (DA) and uric acid (UA). The experimental results showed that the HMOF-Zn@AB-Nafion-GCE sensor had high sensitivity and selectivity for UA and DA. And it was found that it exhibited higher sensitivity for DA than for UA on HMOF-Zn@AB-Nafion-GCE sensor. The high sensitivity and good selectivity of HMOF-Zn@AB-Nafion-GCE sensor for DA and UA are attributed to the synergistic effect of the large surface of HMOF-Zn, the bonding interaction between the analytes (DA or UA) and HMOF-Zn as well as the high conductivity of AB. At the same time, the proposed sensor exhibited excellent linear responses to DA and UA under optimized conditions. The detection ranges were 0.15~2.5 μmol·L-1 for DA and 0.2~4 μmol·L-1 for UA, with the detection limits of 0.003 and 0.02 μmol·L-1, respectively. Moreover, the high reproducibility of the sensor was obtained in all the experiments. The sensor was also successfully applied to the determination of DA in dopamine hydrochloride injection and UA in human urine sample.
Keywords: chirality  metal-organic framework  dopamine  uric acid  electrochemistry
投稿时间:2019-03-26 修订日期:2019-11-07
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方智利,王平,刘胜东,王欣,聂启祥,杨绍明,徐文媛,周枚花.基于手性MOF与乙炔黑修饰电极对多巴胺和尿酸的同时检测[J].无机化学学报,2020,36(1):139-147.
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