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Two Di-n-butyltin Carboxylates with a Sn4O4 Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities |
Author Name | Affiliation | E-mail | FENG Yong-Lan | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China | | KUANG Dai-Zhi | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China | hnkcq@qq.com | ZHANG Fu-Xing | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China | | YU Jiang-Xi | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China | | JIANG Wu-Jiu | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China | | ZHU Xiao-Ming | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China | |
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Abstract: Two di-n-butyltin carboxylates with a Sn4O4 ladder-like framework,[(μ3-O)(μ2-OMe)(n-Bu2Sn)2(O2CR)]2 (R=4-methylphenyl(1), 4-(dimethylamino)phenyl (2)), were obtained by the microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the 4-methylbenzoic acid, 4-dimethylaminobenzoic acid in methanol environments, respectively. The compounds were characterized by elemental analysis, IR, (1H, 13C and 119Sn) NMR spectra and X-ray crystallography diffraction analyses. The compounds have similar structures containing a Sn4O4 ladder-like skeleton, in which two endo-cyclic tin and one exo-tin atoms is bonded to the μ3-O atom, in addition, one endo-cyclic tin and one exo-tin atoms is bonded to the μ2-O atom from the methanol, respectively. The ladder-like molecule has a three-ring fused skeleton, which is almost coplanar. The endo-cyclic and exo-cyclic tin atoms all are five-coordinated with distorted trigonal bipyramid geometry. The antitumor activity shows that compounds 1 and 2 have higher activities than cisplatin in HT-29,HepG2,MCF-7,KB and A549 cell line in vitro. |
Keywords: organotin compound microwave solvothermal synthesis ladder-like framework in vitro antitumor activity |
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FENG Yong-Lan,KUANG Dai-Zhi,ZHANG Fu-Xing,YU Jiang-Xi,JIANG Wu-Jiu,ZHU Xiao-Ming.Two Di-n-butyltin Carboxylates with a Sn4O4 Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities[J].Chinese Journal of Inorganic Chemistry,2017,33(5):830-836. |
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