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Two Di-n-butyltin Carboxylates with a Sn4O4 Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities
Author NameAffiliationE-mail
FENG Yong-Lan Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China  
KUANG Dai-Zhi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China hnkcq@qq.com 
ZHANG Fu-Xing Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China  
YU Jiang-Xi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China  
JIANG Wu-Jiu Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China  
ZHU Xiao-Ming Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, 421008, China  
Abstract: Two di-n-butyltin carboxylates with a Sn4O4 ladder-like framework,[(μ3-O)(μ2-OMe)(n-Bu2Sn)2(O2CR)]2 (R=4-methylphenyl(1), 4-(dimethylamino)phenyl (2)), were obtained by the microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the 4-methylbenzoic acid, 4-dimethylaminobenzoic acid in methanol environments, respectively. The compounds were characterized by elemental analysis, IR, (1H, 13C and 119Sn) NMR spectra and X-ray crystallography diffraction analyses. The compounds have similar structures containing a Sn4O4 ladder-like skeleton, in which two endo-cyclic tin and one exo-tin atoms is bonded to the μ3-O atom, in addition, one endo-cyclic tin and one exo-tin atoms is bonded to the μ2-O atom from the methanol, respectively. The ladder-like molecule has a three-ring fused skeleton, which is almost coplanar. The endo-cyclic and exo-cyclic tin atoms all are five-coordinated with distorted trigonal bipyramid geometry. The antitumor activity shows that compounds 1 and 2 have higher activities than cisplatin in HT-29,HepG2,MCF-7,KB and A549 cell line in vitro.
Keywords: organotin compound  microwave solvothermal synthesis  ladder-like framework  in vitro antitumor activity
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FENG Yong-Lan,KUANG Dai-Zhi,ZHANG Fu-Xing,YU Jiang-Xi,JIANG Wu-Jiu,ZHU Xiao-Ming.Two Di-n-butyltin Carboxylates with a Sn4O4 Ladder-like Framework: Microwave Solvothermal Syntheses, Structures and in Vitro Antitumor Activities[J].Chinese Journal of Inorganic Chemistry,2017,33(5):830-836.
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Chinese Journal of Inorganic Chemistry