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| Syntheses, Crystal Structures and Insulin-like Activity of Maltolato-and Ethylmaltolato-Coordinated Oxovanadium(Ⅴ) Complexes Derived from 4-Fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide |
| Author Name | Affiliation | E-mail | | LI Ling | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | LÜ Kai-Wen | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | LI Yun-Tong | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | JIANG Gui-Fa | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | XIN Yu | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | YE Lei | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | ZHANG Yan | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | LIU Hui | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | SHANG Chao-Nan | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | | | YOU Zhong-Lu | Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China | youzhonglu@126.com |
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| Abstract: A new aroylhydrazone compound 4-fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide (H2L) was prepared. Reaction of H2L and VO(acac)2 with maltol(mat) and ethylmaltol(Emat), respectively, in methanol afforded the complexes[VO(L)(mat)] (1) and[VO(L)(Emat)] (2). Both H2L and the oxovanadium complexes were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra. The structures of the compounds were further confirmed by single crystal X-ray diffraction. The aroylhydrazone ligand, in its dianionic form, coordinated to the V atoms through the phenolate oxygen, imino nitrogen and enolate oxygen. The maltol and ethylmaltol ligands coordinated to the V atoms through the carbonyl oxygen and deprotonated hydroxyl oxygen. The V atom in each complex is in octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgV·kg-1, can significantly decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered. |
| Keywords: aroylhydrazone oxovanadium(Ⅴ) complex crystal structure insulin-like activity |
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| LI Ling,LÜ Kai-Wen,LI Yun-Tong,JIANG Gui-Fa,XIN Yu,YE Lei,ZHANG Yan,LIU Hui,SHANG Chao-Nan,YOU Zhong-Lu.Syntheses, Crystal Structures and Insulin-like Activity of Maltolato-and Ethylmaltolato-Coordinated Oxovanadium(Ⅴ) Complexes Derived from 4-Fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide[J].Chinese Journal of Inorganic Chemistry,2017,33(5):905-912. |
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