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Syntheses, Crystal Structures and Biological Activity of N-(2-Propionic acid)-aroyl Hydrazone Di-p-methylbenzytin Complexes
Author NameAffiliationE-mail
ZHANG Zhi-Jian Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
JIANG Wu-Jiu Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
LIU Yang Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
KUANG Dai-Zhi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
YU Jiang-Xi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
ZHU Xiao-Ming Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
TAN Yu-Xing Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China 358050086@qq.com 
Abstract: Two substituted benzyltin complexes (C1, C2) has been synthesized via the reaction of N-(2-propionic acid)-aroyl hydrazone with di-p-methylbenzytin dichloride. The complexes C1 and C2 have been characterized by IR, UV-Vis, 1H NMR, 13C NMR 119Sn NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines(H460,HepG2, MCF7) and a human cell line(HL7702). Two complexes exhibit strong antitumor activity, moreover, C2 is less toxic than C1. The result of EB fluorescent probe shows the interaction between complexes and calf thymus DNA is intercalation.
Keywords: organotin complex  hydrazone  synthesis  crystal structure  biological activity
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ZHANG Zhi-Jian,JIANG Wu-Jiu,LIU Yang,KUANG Dai-Zhi,YU Jiang-Xi,ZHU Xiao-Ming,TAN Yu-Xing.Syntheses, Crystal Structures and Biological Activity of N-(2-Propionic acid)-aroyl Hydrazone Di-p-methylbenzytin Complexes[J].Chinese Journal of Inorganic Chemistry,2017,33(9):1603-1610.
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Chinese Journal of Inorganic Chemistry