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Syntheses, Crystal Structures and in Vitro Antitumor Activity of Three Bis(organotin) Pyridine-2, 3(5)-dicarboxylate
Author NameAffiliationE-mail
FENG Yong-Lan Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
YU Jiang-Xi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
JIANG Wu-Jiu Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
ZHU Xiao-Ming Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
ZHANG Fu-Xing Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
KUANG Dai-Zhi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China hnkcq@qq.com 
Abstract: Three dinuclear bis(organotin) pyridine-2,3(5)-dicarboxylate, Py(CO)2(SnR3)2(MeOH)n (R:Cy, n=1 (1), 2 (2); R:PhCMe2CH2, n=0 (3)), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide, bis(tri(2-methyl-2-phenyl)propyl)tin oxide with the pyridine-2,3(5)-dicarboxylic acid, respectively. The compounds are characterized by elemental analysis, IR, (1H, 13C, 119Sn) NMR spectra and X-ray crystallography diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. Compound 1 has a 1D supramolecular chain and 2 has a 2D network with 34-membered macrocyclic structure due to the coordinated methanol molecules via hydrogen bonds to the carbonyl oxygen atoms. The antitumor activity shows that these compounds have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.
Keywords: organotin pyridine carboxylate  microwave solvothermal synthesis  in vitro antitumor activity
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FENG Yong-Lan,YU Jiang-Xi,JIANG Wu-Jiu,ZHU Xiao-Ming,ZHANG Fu-Xing,KUANG Dai-Zhi.Syntheses, Crystal Structures and in Vitro Antitumor Activity of Three Bis(organotin) Pyridine-2, 3(5)-dicarboxylate[J].Chinese Journal of Inorganic Chemistry,2018,34(1):99-104.
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Chinese Journal of Inorganic Chemistry