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| Synthesis, Crystal Structure and Antitumor Activity of Pyrazole Zinc Complex |
| Author Name | Affiliation | E-mail | | LI Jing | College of Life Science and Biotechnology, Heilongjiang Bayi Agriculture University, Daqing, Heilongjiang 163319, China | lijingroea@sina.com | | WU Chun-Yang | College of Life Science and Biotechnology, Heilongjiang Bayi Agriculture University, Daqing, Heilongjiang 163319, China | | | ZHANG Ying | College of Life Science and Biotechnology, Heilongjiang Bayi Agriculture University, Daqing, Heilongjiang 163319, China | | | SHEN Gui-Nan | College of Life Science and Biotechnology, Heilongjiang Bayi Agriculture University, Daqing, Heilongjiang 163319, China | | | JIN Cheng-Hao | College of Life Science and Biotechnology, Heilongjiang Bayi Agriculture University, Daqing, Heilongjiang 163319, China | |
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| Abstract: A zinc complex[Zn(Hppo)2(ppo)Cl] (1) (Hppo=3-benzyl-3-pyrazolin-5-one) was synthesized by solvent evaporation and characterized by elemental analysis, FTIR and X-ray diffraction. The complex crystallizes in monoclinic system, space group P21. Cell morphology and in vitro toxicity effects against cancer cell lines HepG2, Hep3B and Huh7 of the complex were investigated. The bioassay results show that this zinc complex has distinct antitumor effects. |
| Keywords: pyrazole antitumor activity metal complex crystal structure |
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| LI Jing,WU Chun-Yang,ZHANG Ying,SHEN Gui-Nan,JIN Cheng-Hao.Synthesis, Crystal Structure and Antitumor Activity of Pyrazole Zinc Complex[J].Chinese Journal of Inorganic Chemistry,2018,34(1):135-141. |
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