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Syntheses, Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure |
Author Name | Affiliation | E-mail | KUANG Dai-Zhi | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | hnkcq@qq.com | YU Jiang-Xi | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | FENG Yong-Lan | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | ZHU Xiao-Ming | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | JIANG Wu-Jiu | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | ZHANG Fu-Xing | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | |
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Abstract: Four bis(tricyclohexyltin)pyridinedicarboxylates, {[(2,6-Hpydc)SnCy3]·MeOH}n (1),[(2,6-pydc)Sn2Cy6(H2O)]·PhH (2),[(3,5-pydc)Sn2Cy6(MeOH)]·MeOH (3) and[(3,5-pydc)Sn2Cy6(H2O)]·EtOH (4), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2,6-H2pydc and 3,5-H2pydc (H2pydc=pyridinedicarboxylic acid), respectively. Compounds 1~4 have been characterized by elemental, IR, (1H, 13C and 119Sn) NMR and single crystal X-ray diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. These compounds has a 2D network with macrocyclic supramolecular by the hydrogen bonding interaction of the neighboring molecule. The antitumor activity showed that compounds 1 and 3 have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro. |
Keywords: tricyclohexyltinpyridinedicarboxylate microwave solvothermal synthesis structure in vitro antitumor activity |
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KUANG Dai-Zhi,YU Jiang-Xi,FENG Yong-Lan,ZHU Xiao-Ming,JIANG Wu-Jiu,ZHANG Fu-Xing.Syntheses, Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure[J].Chinese Journal of Inorganic Chemistry,2018,34(6):1035-1042. |
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