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Syntheses, Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure
Author NameAffiliationE-mail
KUANG Dai-Zhi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China hnkcq@qq.com 
YU Jiang-Xi Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
FENG Yong-Lan Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
ZHU Xiao-Ming Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
JIANG Wu-Jiu Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
ZHANG Fu-Xing Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China  
Abstract: Four bis(tricyclohexyltin)pyridinedicarboxylates, {[(2,6-Hpydc)SnCy3]·MeOH}n (1),[(2,6-pydc)Sn2Cy6(H2O)]·PhH (2),[(3,5-pydc)Sn2Cy6(MeOH)]·MeOH (3) and[(3,5-pydc)Sn2Cy6(H2O)]·EtOH (4), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2,6-H2pydc and 3,5-H2pydc (H2pydc=pyridinedicarboxylic acid), respectively. Compounds 1~4 have been characterized by elemental, IR, (1H, 13C and 119Sn) NMR and single crystal X-ray diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. These compounds has a 2D network with macrocyclic supramolecular by the hydrogen bonding interaction of the neighboring molecule. The antitumor activity showed that compounds 1 and 3 have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.
Keywords: tricyclohexyltinpyridinedicarboxylate  microwave solvothermal synthesis  structure  in vitro antitumor activity
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KUANG Dai-Zhi,YU Jiang-Xi,FENG Yong-Lan,ZHU Xiao-Ming,JIANG Wu-Jiu,ZHANG Fu-Xing.Syntheses, Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin) Pyridinedicarboxylate with Macrocyclic Supramolecular Structure[J].Chinese Journal of Inorganic Chemistry,2018,34(6):1035-1042.
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Chinese Journal of Inorganic Chemistry