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| Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers |
| Author Name | Affiliation | E-mail | | YANG Yong-Mei | School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China
School of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui 245041, China | | | JI Ming-Xiang | School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China | | | YANG Ying | School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China | | | XIE An-Jian | School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China | | | SHEN Yu-Hua | School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China | s_yuhua@163.com |
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| Abstract: A novel sandwich-like nanocomposites of rGO/Fe3O4@mSiO2 were successfully fabricated through a facile method. The morphology and properties of nanocomposites were characterized by SEM, TEM, FTIR, XRD and N2 adsorption-desorption. As a result, it was observed that the nanocomposites exhibit the saturation magnetization of 32 emu·g-1, and possess abundant pores with a large surface area as much as 217 m2·g-1. The loading capacity of Pentafluorouracil (5-FU) with the nanocomposites was high(57.34%). The formation mechanism of rGO/Fe3O4@mSiO2 was discussed. Additionally, the synergistic anticancer efficacy of as-prepared nanocomposites against HeLa cell line was investigated by MTT assay and cell fluorescence microscopic imaging analysis. The results indicated that 5-FU loaded in the nanocoposites is effectively delivered to tumor lesion sites under the action of magnetic targeting. Moreover, the rGO/Fe3O4@mSiO2 nanocomposites have excellent photothermal conversion properties under light conditions, and show significant killing effect on HeLa cells. |
| Keywords: nanocomposite magnetic targeting photo-thermal therapy drug carrier synergistic anti-cancer |
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| YANG Yong-Mei,JI Ming-Xiang,YANG Ying,XIE An-Jian,SHEN Yu-Hua.Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers[J].Chinese Journal of Inorganic Chemistry,2018,34(6):1095-1102. |
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