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Syntheses, Crystal Structures and Urease Inhibition of Two Manganese(III) Complexes with Bis-Schiff Bases
Author NameAffiliationE-mail
LI Yun-Tong Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
DONG Jing-Wen Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
LU Yao Liaoxi Yuming High School, Jinzhou, Liaoning 121000, China  
GU Yi-Tong Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
SHANG Chao-Nan Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
LIU Fu-Yao Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
XIN Yu Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
JING Chang-Ling Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China  
YOU Zhong-Lu Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China youzhonglu@126.com 
Abstract: A bis-Schiff base N,N'-bis(3,5-difluorosalicylidene)-1,3-diaminopropane) (H2L) was prepared. Reaction of H2L and manganese acetate with ammonium thiocyanate or sodium azide in methanol gave complexes[MnL(NCS)(OH2)] (1) and[MnL(μ1,3-N3)]n (2), respectively. H2L and the complexes were characterized by elemental analysis, IR spectra, 1H NMR spectra, and the crystal structures of the complexes were analyzed by single crystal X-ray diffraction. The Schiff base ligand coordinates to the Mn atom through the imino nitrogen and phenolate oxygen. The thiocyanate ligand coordinates to the Mn atom through the nitrogen atom, and the azide ligand coordinates to the Mn atom, with a bridging mode, through two terminal nitrogen atoms. In both complexes, the Mn atoms adopt octahedral coordination. The Schiff base and the complexes were tested for their Jack bean urease inhibitory activities. For complex 1, the inhibition rate at concentration of 100 μmol·L-1 on the urease is (52.0±3.1)%, and the IC50 value is (81.0±3.7) μmol·L-1. While for complex 2, it has no activity against the urease. Molecular docking study of complex 1 was performed to study the inhibition.
Keywords: Schiff base  manganese(III)complex  crystal structure  urease inhibitor
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LI Yun-Tong,DONG Jing-Wen,LU Yao,GU Yi-Tong,SHANG Chao-Nan,LIU Fu-Yao,XIN Yu,JING Chang-Ling,YOU Zhong-Lu.Syntheses, Crystal Structures and Urease Inhibition of Two Manganese(III) Complexes with Bis-Schiff Bases[J].Chinese Journal of Inorganic Chemistry,2018,34(6):1192-1198.
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Chinese Journal of Inorganic Chemistry