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Synthesis, Crystal Structure and DNA Interaction of Mononuclear Osmium Complexes |
Author Name | Affiliation | E-mail | ZHAO Ya-Chen | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | | LI Ji | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | | HU Jiong-Sheng | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | | LIU Lu | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | | WANG Meng-Meng | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | | SU Zhi | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | | QIAN Yong | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | liuhongke@njnu.edu.cn | Peter J. Sadler | Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK | | LIU Hong-Ke | School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China | yongqian@njnu.edu.cn |
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Abstract: Solvothermal reactions of a p-bitmb ligand (4-bis(1-imidazol-1-ylmethyl)-2,3,5,6-tetramethyl benzene) with[Os(arene)Cl2]2 in dichloromethane were used to yield novel mononuclear osmium complexes 1 and 2 (1, arene=p-cym; 2, arene=bip), which were fully characterized by 1H NMR, ESI-MS, elemental analysis and single-crystal X-ray diffraction analysis. X-ray diffraction revealed that 1 is a mononuclear arene-osmium complex, forming a "bowl-like" structure that belongs to monoclinic system with space P21/c. The center osmium atom is coordinated with two nitrogen atom from ligands (p-bitmb) and Cl anion, whereas other imidazole ring of ligand is connected by a-CH2-group to form a dipositive bis-imidazolium center. Cl- anion can be trapped inside the cavity of this "bowl-like" structure, forming H-bonds with the backbone. 1H NMR study showed that the source of the bridging-CH2-group is the solvent, CH2Cl2. These complexes are stable in the buffer solution confirmed by the stability study with UV-Vis spectra. Furthermore, the results of UV-Vis spectra, circular dichroism and viscosity measurements revealed significant interactions between 1, 2 and calf thymus DNA (CT-DNA) via the intercalation, reduction of the base stacking, and induction of the DNA despiralization. |
Keywords: osmium-arene complex crystal structure interaction with DNA |
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ZHAO Ya-Chen,LI Ji,HU Jiong-Sheng,LIU Lu,WANG Meng-Meng,SU Zhi,QIAN Yong,Peter J. Sadler,LIU Hong-Ke.Synthesis, Crystal Structure and DNA Interaction of Mononuclear Osmium Complexes[J].Chinese Journal of Inorganic Chemistry,2018,34(10):1833-1840. |
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