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| Synthesis, Crystal Structure, Anticancer Activity and Interaction with Bovine Serum Albumin of Copper(II) Complex |
| Author Name | Affiliation | E-mail | | ZHANG Yan | School of Chemical and Biological Engineering, Taiyuan Science and Technology University, Taiyuan 030021, China | yanzhang872010@163.com | | MENG Xiang-Gao | College of Chemistry, Central China Normal University, Wuhan 430079, China | | | CAI Ping | College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China | | | CHENG Gong-Zhen | College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China | | | JIA Shi-Fang | School of Chemical and Biological Engineering, Taiyuan Science and Technology University, Taiyuan 030021, China | jiashifang@126.com |
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| Abstract: A four-coordinated Cu(II) complex with Schiff base ligand was synthesized and characterized by the elemental analysis and infrared spectroscopy, and the crystal structure was determined by X-ray diffraction. The crystal of complex belongs to monoclinic system. In vitro antitumor activities of Cu(II) complex were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay against four human cancer cell lines (Hela, SGC-7901, HepG2, MCF-7). Cu(II) complex exhibited stronger antitumor activity than carboplatin. The interaction of Cu(II) complex with bovine serum albumin (BSA) was studied by spectroscopic method. The analysis of fluorescence data indicates the presence of static quenching mechanism in the binding process. Various binding parameters including binding constants, binding sites, binding distance and thermodynamic parameters ΔH, ΔS and ΔG have been evaluated. |
| Keywords: Cu(II)complex crystal structure anticancer activity bovine serum albumin fluorescence spectra |
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| ZHANG Yan,MENG Xiang-Gao,CAI Ping,CHENG Gong-Zhen,JIA Shi-Fang.Synthesis, Crystal Structure, Anticancer Activity and Interaction with Bovine Serum Albumin of Copper(II) Complex[J].Chinese Journal of Inorganic Chemistry,2018,34(10):1864-1874. |
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