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| Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid |
| Author Name | Affiliation | E-mail | | ZHANG Min-Zhi | College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China | | | WU Da-Ling | College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China | | | Shen Wei | College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China | | | ZHAO Guo-Liang | College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China
Xingzhi College, Zhejiang Normal University, Jinhua, Zhejiang 321004, China | sky53@zjnu.cn |
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| Abstract: Three novel transition metal complexes[Co(MTZA)2(H2O)2]·3H2O (1),[Cu(MTZA)2(H2O)]·2H2O (2) and[Zn(MTZA)2(H2O)2]·3H2O (3) have been synthesized by using 2-methyl-4-thiazolecarboxylic acid (HMTZA,C5H5NO2S), structurally confirmed by single crystal X-ray diffraction method, and characterized by elemental analysis, IR analysis and TG. The single crystal X-ray diffraction reveals that complex 1 crystallizes in monoclinic system with space group P21/n. Central Co2+ is six-coordinated to constitute a slightly distorted octahedral structure. Complex 2 crystallizes in triclinic system with space group P1, and its coordination number is five, forming a slightly distorted pentahedral coordination geometry. Complex 3 crystallizes in monoclinic system with space group P21/n. Each Zn2+ is six-coordinated to constitute a distorted octahedral geometry. In addition, DNA-binding of the ligand and complexes were also studied by EtBr fluorescence probe. The interactions of complexes with DNA were stronger than the ligand. |
| Keywords: 2-methyl-4-thiazolecarboxylic acid transition metal complex crystal structure DNA-binding |
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| ZHANG Min-Zhi,WU Da-Ling,Shen Wei,ZHAO Guo-Liang.Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid[J].Chinese Journal of Inorganic Chemistry,2018,34(12):2227-2237. |
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