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| Syntheses, Spectral and Electrochemical Properties, Antitumor Activities of Manganese/Zinc Complexes with Porphyrin Modified by 5-Fluorouracil |
| Author Name | Affiliation | E-mail | | REN Li-Lei | Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang, Hebei 065000, China | renll1409@163.com | | PENG Xiao-Xia | Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang, Hebei 065000, China | | | WANG Shu-Jun | Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang, Hebei 065000, China | d022036@mail.nankai.edu.cn | | XIAO Li-Wei | Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang, Hebei 065000, China | | | LI Ze-Qiang | Faculty of Chemistry and Material Science, Langfang Teachers University, Langfang, Hebei 065000, China | |
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| Abstract: One novel free porphyrin modified with 5-fluorouracil (5-(2-(5-fluorouracil-3-yl)-ethoxyphenyl)-10,15,20-triphenyl porphyrin, L) and its manganese complex (MnL), zinc complex (ZnL) were synthesized. They were characterized by UV-Vis, IR, 1H NMR and MS. Their fluorescence properties and electrochemical properties were examined. The antitumor activities of them were evaluated by SRB assay in vitro against three human cancer cell lines. The results indicate that metal ions have a significant influence on the fluorescence intensity of complexes under the same experimental conditions:the fluorescence quenching was exhibited for zinc complex, but fluorescence signal had not been detected for manganese complex. The cyclic voltammetry of manganese complex was different from those of free porphyrin and zinc complex, which showed not only the redox of porphyrin ring but also the redox of Mn2+ ion. The biological tests revealed that manganese complex has a higher inhibitory rate than L and ZnL, but is less active than 5-fluorouracil. |
| Keywords: metalloporphyrin 5-fluorouracil fluorescence electrochemical property antitumor activity |
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| REN Li-Lei,PENG Xiao-Xia,WANG Shu-Jun,XIAO Li-Wei,LI Ze-Qiang.Syntheses, Spectral and Electrochemical Properties, Antitumor Activities of Manganese/Zinc Complexes with Porphyrin Modified by 5-Fluorouracil[J].Chinese Journal of Inorganic Chemistry,2019,35(6):965-970. |
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