|
| Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand |
| Author Name | Affiliation | E-mail | | LIU Jiao | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | LI Zhuo-Qun | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | YI Yu-Yang | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | ZHONG Yi-Xin | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | YU Hao-Tian | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | TAN Yu-Xing | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | | | JIANG Wu-Jiu | Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China | jwj_china@163.com |
|
| Abstract: Four dinuclear benzyltin complexes were synthesized by microwave "one-pot synthesis", namely {[C4H3S(O)C=N-N=C(Me)COO](PhCH2)2Sn(MeOH)}2 (C1), {[C4H3S(O)C=N-N=C(Me)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2 (C2), {[C4H3S(O)C=N-N=C(PhCH2)COO](PhCH2)2Sn(MeOH)}2 (C3), {[C4H3S(O)C=N-N=C(PhCH2)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2 (C4). The complexes C1~C4 were characterized by IR, 1H NMR, 13C NMR 119Sn NMR spectra, elemental analysis, HRMS and the crystal structures were determined by X-ray diffraction. The four complexes are all binuclear molecules, and there was a Sn2O2 four-membered ring in the middle of the molecule. The central tin atom and the coordinating atom form a seven-coordinated pentagonal bipyramid configuration. The thermogravimetric of the complexes C1~C4 were analyzed, and in vitro antitumor activities of the complexes were evaluated by MTT against three human cancer cell lines (H460, HepG2, MCF7). The results show that complex C2 is the best compound for inhibiting cancer cells in the four synthesized complexes. |
| Keywords: organotin complex acylhydrazone synthesis crystal structure activity |
| Hits: 1226 |
| Download times: 570 |
| LIU Jiao,LI Zhuo-Qun,YI Yu-Yang,ZHONG Yi-Xin,YU Hao-Tian,TAN Yu-Xing,JIANG Wu-Jiu.Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand[J].Chinese Journal of Inorganic Chemistry,2019,35(12):2200-2208. |
| View Full Text View/Add Comment Download reader |
|
|
|
|
|
|
|
|
