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| Synthesis, Crystal Structure, and Antibacterial Activity of Copper(Ⅱ) Complexes Based on Norfloxacin |
| Author Name | Affiliation | E-mail | | HUANG Yan-Ju | Department of Chemistry, Tonghua Normal University, Tonghua, Jilin 134002, China | huangyanju2007@163.com | | XU Mei-Ling | Department of Chemistry, Tonghua Normal University, Tonghua, Jilin 134002, China | | | ZHANG Jun | Department of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei 230601, China | |
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| Abstract: Two copper complexes[Cu2(HNOR)2Cl]n (1) and[Cu2Cl3]·H3NOR·H2O (2) (H2NOR=norfloxacin) were prepared by hydrothermal process and their structures were determined by single-crystal X-ray diffraction. The results showed that although the reactants are the same, the complexes with different structures are formed under acidic and basic conditions. Through the hydrogen bonding interactions and π-π interactions, two complexes form stable two-dimensional structure. At the same time, Escherichia coli and Staphylococcus aureus were selected as Gram positive and Gram negative for antibacterial activity experiments. Bacteriostatic activity showed that both complexes had a good inhibitory effect on Escherichia coli and Staphylococcus aureus. |
| Keywords: norfloxacin copper complexes antibacterial activity two-dimensional structure |
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| HUANG Yan-Ju,XU Mei-Ling,ZHANG Jun.Synthesis, Crystal Structure, and Antibacterial Activity of Copper(Ⅱ) Complexes Based on Norfloxacin[J].Chinese Journal of Inorganic Chemistry,2020,36(3):515-520. |
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