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Viscosity Responsive and Mitochondria Targeted Iridium(Ⅲ) Complexes for Photodynamic Therapy of Tumors |
Author Name | Affiliation | E-mail | OUYANG Ai | College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China | | LUO Yu-Heng | College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China | | LU Nong | College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China | | HU Ren-Tao | College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China | | ZHANG Ping-Yu | College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China | p.zhang6@szu.edu.cn | ZHANG Qian-Ling | College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China | zhql@szu.edu.cn |
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Abstract: Two novel iridium(Ⅲ) complexes (Ir1 and Ir2) containing rotatable groups were designed and synthesized for viscosity probes and photosensitizers. Firstly, they freely rotated and showed weak phosphorescence in lowviscosity environment, while in viscous media, the phosphorescence intensity increased significantly (35.7-fold for Ir1, 1 311.6 -fold for Ir2). The cellular uptake and co -localization studies indicated that the probes could easily cross the cell membrane and aggregate in mitochondria, and the results showed that they could be used for detection of mitochondrial viscosity. Moreover, Ir1 and Ir2 displayed high potent photo-cytotoxicity to cancer cells (A549 and Hep-G2) under light irradiation but exhibited lower photo-cytotoxicity to normal cells (MRC-5 and LO2). The generation of 1O2 under light irradiation were also measured by electron paramagnetic resonance (EPR) and confocal microscopy. |
Keywords: iridium(Ⅲ) complexes viscosity-response mitochondria-targeting photodynamic therapy |
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OUYANG Ai,LUO Yu-Heng,LU Nong,HU Ren-Tao,ZHANG Ping-Yu,ZHANG Qian-Ling.Viscosity Responsive and Mitochondria Targeted Iridium(Ⅲ) Complexes for Photodynamic Therapy of Tumors[J].Chinese Journal of Inorganic Chemistry,2021,37(3):401-411. |
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