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| Tumor-Targeted Pt-Cu Nanoplatform for Photothermal Therapy Guided by the Second Near-Infrared Window Photoacoustic Imaging |
| Author Name | Affiliation | E-mail | | ZHENG Zi-Liang | Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China | | | QU Bo-Tao | Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China | | | YANG Xiao-Rong | Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China | | | LIU Ling | Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China | | | ZHANG Rui-Ping | Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China | zrp_7142@sxmu.edu.cn |
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| Abstract: A nanoplatform Pt-Cu@PLL@HA based on PtCu nano-alloys encapsulated in the positively charged polylysine (PLL) and negatively charged hyaluronic acid (HA) was constructed via layer-by-layer (LBL) self-assem-bly technology. HA not only prolonged the blood circulation time of Pt-Cu@PLL@HA, but also realized the active tumor targeting and enhanced its high accumulation in tumor region. After fast HA degradation in response to hyaluronidase (HAase) in the tumor microenvironment, the site-specific exposure of Pt-Cu@PLL(+) was conducive to the uptake of tumor cells. Owing to the strong NIR-Ⅱ (the second near-infrared window) absorption capability of Pt-Cu alloy, the effective photothermal tumor ablation could be realized by the precise guidance of NIR-Ⅱ photoacoustic imaging. |
| Keywords: the second near-infrared window photothermal therapy photoacoustic imaging Pt-Cu alloy layer-by-layer self-assembly |
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| ZHENG Zi-Liang,QU Bo-Tao,YANG Xiao-Rong,LIU Ling,ZHANG Rui-Ping.Tumor-Targeted Pt-Cu Nanoplatform for Photothermal Therapy Guided by the Second Near-Infrared Window Photoacoustic Imaging[J].Chinese Journal of Inorganic Chemistry,2021,37(11):1991-2001. |
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