| 在胆酸盐介质中用氨羧配位剂溶解胆红素钙的动力学研究 |
| STUDY ON DISSOLUTION OF CALCIUM BILIRUBINATE PELLET WITH POLYAMINOCARBOXYLATES IN BACKGROUND OF SODIUM CHOLATE |
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| 摘要: 以胆红素及其钙盐为主要成分的色素型胆结石病在国内为常见病,多年来曾研究用钙配位剂溶石的可能性,但效果不明显,主要由于对配位剂溶石机理了解不够.为此本文在模拟胆汁背景条件下,用氨羧配位剂溶解模拟结石的胆红索钙压片进行了动力学研究,其结果有利于阐明胆色素结合配位溶解的机理和决定溶石效果的因素. |
| 关键词: 胆红素钙 氨羧配位剂 动力学 |
| 基金项目: 中国科学院科学基金资助的课题 |
| Abstract: In order to clarify the development of a chemical model simulating the chelating dissolution treatment of this kind of stone, the processes of the dissolution of calcium bilirubinate pellet with complexones(EHTA, EDTA, NTA, DTPA)in the presence of sodium cholate were studied by means of static method, which is similar with that used by higuchi for the studies of dissolution of cholesterol. The rate of dissolution as well as the limit of dissolution were determined through the monitoring of calcium(with atomic absorption spectroscopy)and bilirubin(with spectro-photometric method). The calcium bilirubinate is of a composition of Ca: Bilirubin=1:1. The results show that Ca and bilirubin are dissolved in two different routes, thus the amount of Ca dissolved is much higher than that of bilirubin, while the dissolution rate of Ca is much higher than that of bilirubin as well. The solubilities of calcium bilirubinate pellet in four complexones decrease as such:EGTA>DTPA>EDTA>NTAwhich is roughly parallel with the conditional stability constants sequence of their calcium complexes. |
| Keywords: caleium bilirubinate polyaminocarboxylate kinetics |
| 投稿时间：1986-11-08 |
| 摘要点击次数: 1597 |
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| 计季,许善锦,王夔.在胆酸盐介质中用氨羧配位剂溶解胆红素钙的动力学研究[J].无机化学学报,1987,3(3):82-90. |
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