| 具有抗HIV病毒活性的杂多酸HPA-23与谷胱甘肽的作用 |
| INTERACTIONS OF HETEROPOLYTUNGSTATE HPA-23 WITH GLUTATHIONE STUDY BY NMR SPECTROSCOPY |
|
| 摘要: 以谷胱甘肽作为病毒包络蛋白的模拟物,用NMR方法研究了与具有抗爱滋病病毒活性杂多酸HPA-23的作用。对不同配比的HPA-23和谷胱甘肽混合物的1H和183WNMR谱研究结果表明,还原型和氧化型谷胱甘肽均以C末端COO-与HPA-23骨架的钨原子配位,还原型谷胱甘肽侧链上的巯基(SH)也参加配位。COSY谱证明了SH配位为慢交换反应。早在七十年代初,人们就发现杂多酸具有抗病毒活性[1,2].最近报道[NH4< |
| 关键词: 核磁共振 杂多酸 谷胱甘肽 |
| 基金项目: 国家自然科学基金 |
| Abstract: The interactions of heteropolytungstate HPA-23 known to exhibit human immunodeficiency virus with glutathione(GSH and GSSG) used as model for envelope protein of the virus have been investigated by 1H and 183W NMR spectroscopy. Both GSH and GSSG interact with atoms W in the framework of HPA-23 by the COO- group of C-termal. The SH group in the side chain of GSH is also bound to HPA-23, and this process is verified to be slowly exchange by COSY. |
| Keywords: NMR heteropolytungstate glutathione |
| 投稿时间：1993-03-24 |
| 摘要点击次数: 1252 |
| 全文下载次数: 1351 |
| 赵大庆,高新风,吴亦洁,孝延文,裴奉奎,倪嘉缵,刘景福,刘娅.具有抗HIV病毒活性的杂多酸HPA-23与谷胱甘肽的作用[J].无机化学学报,1994,10(2):155-159. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: |
|
|
|
|
|
|
