| Abstract: Diethyldithiocarbamate (DDTC), dihydroxyethyldithiocarbamate (DHED), N-benzyl-D-glucaminedithiocarbamate (BGD), meso-2,3-dimercapto-succinic acid (DMSA) and trans-1,2-cyclohexane-diamine N,N,N′,N′-tetraacetic aicd (CDTA) were studied for their protective effects against the renal toxicity in mice induced by acute exposure to nickel (Ni). Mice were injected intraperitoneally with NiCl2 (5 mg Ni/kg) and 30 min or 24 h later, they were injected intraperitoneally with chelating agents (400 μmol/kg). Ni injection increased lipid peroxidation (LPO), serum creatinine, blood urea nitrogen (BUN) and concentrations of Ni, Ca, Fe and Zn. BGD, DMSA and DDTC significantly prevented the increase in those changes caused by Ni injection. The results indicated that BGD was more effective chelating agents in protecting against Ni-induced renal damage. |
