| 磺酸基邻苯二甲酰亚氨甲基酞菁锌的合成及光动力抗肿瘤活性研究 | |
| STUDIES ON THE SYNTHESIS AND PHOTODYNAMIC ANTITUMOUR ACTIVITY OF SULFONATED PHTHALIMIDOMETHYL PHTHALOCYANINE ZINC | |
| 摘要: 合成了含不同数目磺酸基(以S表示)和邻苯二甲酰亚氨甲基(以P表示)的酞菁锌配合物的混合物，采用反相高效液相色谱进行分离，得到的D组分，经元素分析其组成为ZnPcS2P2两亲性配合物，对该配合物进行了IR、UV/Vis光谱表征，并研究了其在体对S180和U14实体瘤的光动力活性和机理。 | |
| 关键词: 两亲性酞菁锌 合成 光动力活性 抗肿瘤机理 | |
| 基金项目: | |
| Abstract: Zinc phthalocyanines subsituted to different degrees with hydrophilic sulfphonic acid and hydrophobic phthalimidomethyl groups were synthesized and separated on a semi-preparative reverse phase HPLC column packed with ODS(C-18) spherisob. The ZnPcS2P2 was obtianed and characterized by elemental analyses, IR spectra and UV/Vis spectra. The photodynamic therapy effects of ZnPcS2P2 in vivo showed that growth of S180 and U14 solid carcinoma was inhibited significantly. The inhibitory rate was 76.7% and 68.7% respectively. Its antineoplastic mechanism by PDT was also researched preliminarily. | |
| Keywords: hydrophilic-lipophilic zinc phthalocyanine synthesis photodynamic activity antineoplastic mechanism | |
| 摘要点击次数: 1917 | |
| 全文下载次数: 1884 | |
| 刘尔生,黄剑东,戴志飞,杨素苓,吴谊群,陈耐生,黄金陵,黄自强,孙建成,许建华.磺酸基邻苯二甲酰亚氨甲基酞菁锌的合成及光动力抗肿瘤活性研究[J].无机化学学报,1997,13(4):411-415. | |
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