| 2-氯代苯甲醛丙氨酸席夫碱类抗癌药物对DNA作用的谱学研究 |
| SPECTRAL STUDY ON ACTION MODES OF SOME ANTICANCER AGENTS OF THE SCHIFF BASE AND ITS METAL COMPLEXES THAT DERIVED FROM 2-CHLOROBENZALDEHYDE AND ALANINE |
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| 摘要: 合成了2-氯代苯甲醛丙氨酸钾席夫碱(C10H9CINO2K·H2O，简写为2-CAK)及其Cu(Ⅱ)、Zn(Ⅱ)、Co(Ⅱ)、Ni(Ⅱ)金属配合物［Cu(2-CA)2］(C20H18Cl2N2O4Cu·2H2O)、［Zn(2-CA)2］(C |
| 关键词: 席夫碱及其配合物 DNA 荧光光谱 表面增强拉曼散谢 |
| 基金项目: |
| Abstract: Schiff base, which derived from 2-chlorobenzaldehyde and alanine (C10H9ClNO2K·H2O, 2-CAK), and its Cu(Ⅱ), Zn(Ⅱ), Co(Ⅱ), Ni(Ⅱ) complexes (［Cu(2-CA)2］(C20H18Cl2N2O4Cu·2H2O), ［Zn(2-CA)2］(C20H18Cl2N2O4Zn·4H2O), ［Co(2-CA)2］(C20H18Cl2N2O4Co·H2O), ［Ni(2-CA)2］(C20H18Cl2N2O4Ni·2H2O) have been synthesized for the first time. The effects of these compounds on DNA have been studied by the UV-Vis, Fluorescence and SERS spectra method. The significant increase and shiftiness in intensity and wavenumbers of 2-CAZn upon binding to DNA is attributed to the formation of a simple 2-CAZn-DNA complex. The results show that 2-CACo、 2-CAZn have strong interactions with DNA. Their acting ways on DNA are different. It is worthy to do a further research on these compounds as anticancer drugs. |
| Keywords: Shiff base and their complex DNA fluorescence spectrum surface-enhanced Raman spectrum |
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| 叶勇,胡继明,曾云鹗,严振寰,陈建.2-氯代苯甲醛丙氨酸席夫碱类抗癌药物对DNA作用的谱学研究[J].无机化学学报,1998,14(1):84-91. |
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