| 人红细胞摄入Cd2+离子的动力学和机理 |
| Kinetics and Mechanisms of the Uptake of Human Erythrocytes for Cd 2+ Ions |
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| 摘要: 不同Cd2+离子浓度引起的人红细胞相对溶血率及临界溶血浓度CH0已经测定,CH0=2.5×10-4mol·L-1。Cd2+跨膜进入人红细胞遵从一级动力学过程,其一级速率常数为1.2×10-2h-1。阴离子通道抑制剂DIDS及K+,Na+-ATPase抑制剂均可部分抑制人红细胞摄入Cd |
| 关键词: 镉 细胞摄取 人红细胞 |
| 基金项目: 国家自然科学基金(No.29571007) |
| Abstract: The Cd 2+-induced relative hemolysis rate and critical hemolysis concentration(CH0) of human erythrocythes were determined, CH0 is 0.25mmol·L-1. The uptake of human erythrocythes for Cd 2+ followed a first order kinetic process with rate constant k =1.2×10-2 h-1. DIDS and Oubain, the former is inhibitor of anion channel and the latter is of Na+, K+ ATP ase, all inhibited partly the cellular uptake of Cd 2+. The concentration of Cl- and pHvalues in medium effected the cellular uptake. The uptake amount of Cd increased lineally with concentrations of Cd2+ outside the cells. These results indicated that the uptake of human erythrocytes for Cd 2+ is a complex process involving simple passive diffusion, carrier transfer through aniom channel and active transport. |
| Keywords: cadmium cellular uptake human erythrocytes |
| 投稿时间：1999-12-23 |
| 摘要点击次数: 1482 |
| 全文下载次数: 1886 |
| 吴刚,李荣昌,齐秀文,王夔.人红细胞摄入Cd2+离子的动力学和机理[J].无机化学学报,2000,16(2):279-286. |
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