| 三苦味酸根·2,2'-二硫代二(N-氧化吡啶)合稀土(Ⅲ) 配合物的合成、表征及其抗肿瘤活性研究 |
| Synthesis, Characterization and Antitumor Research of Tripicrate (2,2'-dithiobis (Pyridine-N-oxide)) Rare Earth(Ⅲ) Complexes |
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| 摘要: |
| 关键词: 2,2'-二硫代二(N-氧化吡啶) 稀土苦味酸盐 合成 表征 抗肿瘤活性 |
| 基金项目: |
| Abstract: Six rare earth picrate complexes with 2, 2'-dithiobis (pyridine-N-oxide) (L) have been synthesized.The ligand Lacts only as an N-oxide oxygen donor.The complexes were characterized by elemental analysis, and IR, and antitumor activity of [La(pic),L]·EtOH, [Eu(pic),L]·EtOH and [Er(pic)3L]·EtOH complexes were tested with L1210 and HL-60 cells, the preliminary results of in vitro test show that the inhibitory effects of the complexes were significantly greater than that of ligand.Eu (Ⅲ) complex to HL-60, La, Eu and Er complexes to L1210 all exhibit significant cytotoxicity and have potential prospect to be further developed. |
| Keywords: 2,2'-dithiobis (pyridine-N-oxide) rare earth picrate synthesis characterization antitumor activity |
| 投稿时间：2000-12-05 修订日期：2001-02-01 |
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| 张永平,范丽岩,唐宁,谭民裕.三苦味酸根·2,2'-二硫代二(N-氧化吡啶)合稀土(Ⅲ) 配合物的合成、表征及其抗肿瘤活性研究[J].无机化学学报,2001,17(3):427-430. |
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