| 一种新型钌(Ⅱ)-组氨酸配合物[RuCl(Me2SO)2(L-His)]·H2O的合成及其结构表征 |
| Synthesis and Structural Characterization of a Novel Ruthenium(Ⅱ)- Histidine Complex |
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| 摘要: 本文通过将抗癌活性化合物cis-[RuCl2(Me2SO)4]与L组氨酸在乙醇溶液中或在溶剂热条件下反应均得到了配合物[RuCl(Me2SO)2(L-His)](1)。X-射线单晶结构分析表明该配合物的晶体属变形八面体,空间群P3121,a=b=14.0575(16)Å,c=15.637(3)Å分子中含一个结晶水。该配合物中L-组氨酸配体分别通过氨基氮、咪 |
| 关键词: 钌(Ⅱ)配合物 组氨酸 晶体结构 抗癌药物 |
| 基金项目: 国家自然科学基金资助项目(No.29925102). |
| Abstract: The reaction of anti metastatic agent cis-[RuCl2(Me2SO)4] with L-histidine in ethanolic solution or under solvothermal conditions results in the formation of [RuCl(Me2SO)2(L-His)](1).The Xray structure analysis shows that the Ru(Ⅱ)atom in the complex 1 has a distortedly octahedral coodination,P3121,a=b=14.0575(16)Å,c=15.637(3)Å,with one crystallized water molecule. The histidine ligand coordinated to Ru(Ⅱ)in a facial tridentate mode through amino nitrogen, imidazole nitrogen and carboxylate oxygen, respectively. |
| Keywords: ruthenium complex histidine crystal structure anticancer agent |
| 投稿时间：2001-05-16 修订日期：2001-06-29 |
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| 柯晓康,张俊勇,涂超,刘琴,熊仁根,郭子建.一种新型钌(Ⅱ)-组氨酸配合物[RuCl(Me2SO)2(L-His)]·H2O的合成及其结构表征[J].无机化学学报,2001,17(5):653-658. |
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