| 环糊精-苯丙氨酸超分子体系的包合现象与分子识别 |
| Inclusion Phenomena and Molecular Recognition Study on the Supramolecular System of Cyclodextrins-Phenylalanine |
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| 摘要: 通过紫外-可见光谱探讨了水溶液中α-环糊精(CD 1),β-CD 2,七(2, 6-二-o-甲基)-β-CD 3和γ-CD 4与D-、L-、D,L-苯丙氨酸(Phe)形成超分子包合物的稳定常数(K)。手性或外消旋苯丙氨酸与同一主体结合能力的强弱顺序为:L- >D,L- >D-Phe,各体系的KL/KD值在1.65～3.01之间,给出了较好的异构体分离。但三种形式的苯丙氨酸与这些主体的缔合常数均较小(K< 3×102mol·L-1)。就不同主体而言,K值的次序为:3 >1 >4 >2,并不完全等同于KL/KD的顺序:2 >1 >3 >4。 |
| 关键词: 环糊精 苯丙氨酸 包合物 分子识别 |
| 基金项目: |
| Abstract: The association constant values, K, for the interaction of α-CD 1, β-CD 2, heptakis(2,6-di-o-methyl)-β-CD 3 and γ-CD 4 with D-,L-,D,L-phenylalanine (Phe) were determined by means of UV-vis spectroscopy. The order of the K value is L- >D,L- >D-Phe for the same host. The KL/KD value is between 1.65 and 3.01, indicating that an optically active isomer can be effectively separated by means of inclusion compounds formation. The order of the KL/KD value (2 >1 >3 >4) is different from that of the K value (3 >1 >4 >2). |
| Keywords: cyclodextrin amino acid inclusion compound molecular recognition |
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| 宋乐新,赵亮,郭子建.环糊精-苯丙氨酸超分子体系的包合现象与分子识别[J].无机化学学报,2002,18(9):897-901. |
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