| 4-(3-吲哚基)-3-丁烯-2-酮苯甲酰腙Schiff碱过渡金属配合物的合成、表征及生物活性研究 | |
| Synthesis, Characterization and Biological Activities of Transition Metal Complexes with Schiff Base Ligand 4-[Indol-3-yl]-but-3-en-2-one Benzoyl Hydrazone | |
| 摘要: | |
| 关键词: 席夫碱 过渡金属配合物 合成 表征 生物活性 | |
| 基金项目: | |
| Abstract: A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2，M=Cu(Ⅱ), Ni(Ⅱ), Zn(Ⅱ) and Co(Ⅱ)) have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF. | |
| Keywords: Schiff base transition metal complex synthesis characterization biological activity | |
| 投稿时间：2004-11-15 修订日期：2005-01-26 | |
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| 孙纲春,曲建强,王流芳,陈耐生,李燕,陈晓光,谢晶曦.4-(3-吲哚基)-3-丁烯-2-酮苯甲酰腙Schiff碱过渡金属配合物的合成、表征及生物活性研究[J].无机化学学报,2005,21(7):1069-1072. | |
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