| 高频超声照射下血卟啉镓配合物对脱氧核糖核酸的损伤 |
| Damage of Deoxyribonucleic Acid under High Frequency Ultrasonic Irradiation in the Presence of Hematoporphyrin-Ga Complex |
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| 摘要: 用紫外-可见(UV-Vis)光谱和荧光(FL)光谱研究了高频超声波激活血卟啉镓(HP-Ga)配合物对脱氧核糖核酸(DNA)的损伤，并探讨了超声波照射时间、HP-Ga浓度、溶液酸度和离子强度等因素对DNA损伤的影响。结果表明，在一定条件下，DNA的损伤程度随着超声波照射时间的增加和HP-Ga浓度的增大而加剧，而溶液酸度和离子强度的影响则较为复杂。 |
| 关键词: 超声波 血卟啉镓(HP-Ga)配合物 损伤 脱氧核糖核酸(DNA) |
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| Abstract: The damage of deoxyribonucleic acid (DNA) under the action of hematoporphyrin-Ga (HP-Ga) complex activated by ultrasound was detected by means of ultraviolet-visible (UV-Vis) and fluorescence (FL) spectroscopy, and the influences of ultrasonic irradiation time, HP-Ga concentration, solution acidity and ionic strength were also discussed. The results showed that under a certain condition, the damage of DNA could be enhanced with the increase of ultrasonic irradiation time and HP-Ga concentration. However, the influences of solution acidity and ionic strength on the damage of DNA were more complicated. |
| Keywords: ultrasound hematoporphyrin-Ga (HP-Ga) complex damage deoxyribonucleic acid (DNA) |
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| 王君,熊大珍,张朝红,张向东,陈立江,赵红丹,邢志强,徐锐.高频超声照射下血卟啉镓配合物对脱氧核糖核酸的损伤[J].无机化学学报,2007,23(3):479-483. |
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