| 两种三齿多吡啶铜(Ⅱ)配合物的合成、表征及其与DNA的作用 |
| Two Copper(Ⅱ) Complexes with Tridentate Polypyridyl Ligands: Synthesis， Characterization and Their Interaction with DNA |
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| 摘要: 本文合成了2个三齿多吡啶铜(Ⅱ)配合物[Cu(phpi)Cl2]·H2O和[Cu(tpy)Cl2]·2H2O(phpi=2-(苯并咪唑基-2)-1，10-邻菲咯啉，tpy=2，2:6′，2″-三联吡啶)，并通过元素分析、摩尔电导率、红外光谱、紫外光谱对其进行了表征。应用电子吸收光谱、荧光光谱和粘度法研究了配合物与DNA的相互作用。在抗坏血酸存在下，利用琼脂糖凝胶电泳方法研究了配合物对pBR322 DNA的切割作用并对其作用机理作了初步探讨。 |
| 关键词: 铜(Ⅱ)-三齿配合物 2，2:6′，2″-三联吡啶 2-(苯并咪唑基-2)-1，10-邻菲咯啉 DNA |
| 基金项目: |
| Abstract: Two copper(Ⅱ) complexes [Cu(phpi)Cl2]·H2O (1) and [Cu(tpy)Cl2]·2H2O (2) (phpi=2-(benzimidazol-2)-1，10-phenanthroline， tpy=2，2:6′，2″-terpyridine) were synthesized and characterized by elemental analysis， molar conductivity， IR and UV spectroscopy. The interaction of the two complexes with DNA was also studied by electronic absorption spectroscopy， ethidium bromide (EB) fluorescence spectroscopy， viscosity and gel electrophoresis measurements. It was found that the two complexes could cause significant cleavage of double-strand pBR322 DNA in the presence of ascorbic acid. In addition， the mechanism of DNA cleavage was primarily suggested. |
| Keywords: copper tridentate complexes 2, 2:6′,2″-terpyridine 2-(benzimidazol-2)-1,10-phenanthroline DNA |
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| 林庆斌,曾锡瑞,倪春林,李智斌,庄楚雄,乐学义.两种三齿多吡啶铜(Ⅱ)配合物的合成、表征及其与DNA的作用[J].无机化学学报,2007,23(8):1341-1346. |
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