| 药物-无机复合材料姜黄素嵌入镁铝水滑石的合成、表征及缓释性能的研究(英文) |
| Synthesis, Characterization and Release of Curcumin-intercalated Mg-Al-Layered Double Hydroxides |
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| 摘要: 采用共沉淀和离子交换方法将药物姜黄素(Cur)嵌入到Mg-Al-LDHs层间，制备了一种新型的药物-无机复合材料，借助XRD，FTIR和TG-DTA等手段对样品进行了表征。结果表明，Cur阴离子以平行或者单层、沿其短轴方向垂直嵌入到层间；与主体层板通过氢键与静电作用形成超分子结构；该超分子结构姜黄素-水滑石复合材料与姜黄素相比，其热稳定性、耐酸性及缓释性能均有大幅度提高，缓释实验数据符合Bhaskar方程和一级动力学方程模型。 |
| 关键词: 水滑石 姜黄素 药物-无机复合材料 热稳定性 缓释 |
| 基金项目: |
| Abstract: A drug-inorganic clay composite involving a pharmaceutically active compound curcumin(Cur) intercalated Mg-Al layered double hydroxides(Cur-LDHs) with nMg/nAl=3.0, has been assembled by co-precipitation and ion exchange methods. XRD and FTIR results indicate a successful intercalation of Cur between the layers with monolayer horizontal(parallel to the layer) and vertical(perpendicular to the layer) orientations of Cur anion. TG-DTA results show that the thermal stability of intercalated organic species is greatly enhanced due to host-guest interaction involving the hydrogen bond compared to pure form before intercalation. The release studies show that release percentages decrease with increasing pH value from 4.0 to 6.5. The kinetic simulation for the release data indicates that the dissolution mechanism is mainly responsible for the release behavior of Cur-LDHs at pH value of 4.0, while the ion-exchange one is responsible for that at pH value of 6.5. |
| Keywords: layered double hydroxides curcumin drug-inorganic composite thermal stability sustain-release |
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| 曹根庭,邢方方,王 平,倪哲明.药物-无机复合材料姜黄素嵌入镁铝水滑石的合成、表征及缓释性能的研究(英文)[J].无机化学学报,2008,24(6):956-963. |
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