| 手性双核钌(Ⅱ)配合物与DNA的相互作用研究 | |
| Interaction between DNA and Chiral Dinuclear Ru(Ⅱ) Complexes | |
| 摘要: 本文合成了1对手性双核钌(Ⅱ)配合物ΔΔ-和ΛΛ-[(bpy)2Ru(mbpibH2)Ru(bpy)2](ClO4)4(bpy=2，2′-联吡啶，mbpibH2=1，3-二(咪唑并[4，5-f][1，10-邻菲咯啉])苯)。通过元素分析、质谱、核磁共振、CD光谱对这两个化合物进行了结构表征。采用循环伏安法对配合物的电化学性质进行了分析。利用紫外-可见吸收光谱滴定、荧光光谱滴定 | |
| 关键词: 钌(Ⅱ)配合物 手性配合物 DNA键合 | |
| 基金项目: | |
| Abstract: The enantiomerically-pure chiral dinuclear Ru(Ⅱ) complexes ΔΔ- and ΛΛ-[(bpy)2Ru(mbpibH2)Ru(bpy)2](ClO4)4(bpy=2,2′-bipyridine, mbpibH2=1,3-bis([1,10]phenanthroline-[5,6-d]imidazol-2-yl)benzene) were synthesized and characterizated by elemental analysis, MS, 1H NMR and CD spectra. The electrochemical behaviors of the complexes have been studied by cyclic voltammetry. Binding of the complexes with CT-DNA has been investigated by absorption titration, luminescence titration, steady-state emission quenching and viscosity experiments. The results indicate that both the enantiomers can intercalate into CT-DNA while the binding ability of ΔΔ is stronger than that of ΛΛ. | |
| Keywords: Ru(Ⅱ) complexes chiral complexes DNA binding | |
| 摘要点击次数: 1959 | |
| 全文下载次数: 1899 | |
| 袁益娴,陈 禹,王贻灿,梁思敏,巢 晖,计亮年.手性双核钌(Ⅱ)配合物与DNA的相互作用研究[J].无机化学学报,2008,24(8):1265-1271. | |
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