| 双核锰配合物[Mn2(Adpa)2Cl4]的合成、与线粒体和癌细胞的作用(英文) |
| Synthesis, Interaction with Mitochondrial and Cancer Cells of a Dinuclear Manganese(Ⅱ) Complex: Mn2(Adpa)2Cl4 |
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| 摘要: 本文以N-烯丙基二吡啶甲基胺为配体，合成了一个新的锰配合物。晶体结构显示其为双核锰(Ⅱ，Ⅱ)配合物。用MTT法研究了双核锰配合物体外与线粒体作用和对肿瘤细胞生长的抑制作用。 实验结果表明双核锰(Ⅱ，Ⅱ)配合物对癌细胞ECA-109有较强的抑制作用，且化合物能抑制过量钙离子引起的线粒体肿胀。 |
| 关键词: 双核锰配合物 癌细胞 线粒体肿胀 |
| 基金项目: |
| Abstract: A dinuclear manganese(Ⅱ, Ⅱ) complex Mn2(Adpa)2Cl4 (Adpa=N-allyl di(picolyl)amine) was synthesized and the crystal structure was determined using X-ray diffraction crystal structure analysis. The bioassay results show complex was active against the four kinds of cancer cells (HepG 2, Eca-109, LoVo, A549) with IC50 in the range 25～65 μmol·L-1, and it was found that the complex activated the proliferation of cancer cell A549 in the range of 1～20 μmol·L-1. The interaction between ct-DNA and complex is weak, but the complex can inhibit the induced swelling of Ca2+-loaded mitochondria swelling in a dose-dependent manner in vitro. CCDC: 658318. |
| Keywords: dinuclear manganese(Ⅱ) complex cancer cells mitochondria swelling |
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| 陈秋云,黄 娟,李军峰,高 静.双核锰配合物[Mn2(Adpa)2Cl4]的合成、与线粒体和癌细胞的作用(英文)[J].无机化学学报,2008,24(11):1789-1793. |
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