| Abstract: Two organosulfonate complexes, [M(phen)2(ans)2]·H2O (M=Cd 1, M=Pb 2), were obtained from the reaction of 1,10-phenanthroline (phen), sodium 4-aminonaphthalene-1-sulfonate tetrahydrate (Naans) and Cd(OAc)2·2H2O or Pb(NO3)2 in a mixed solvent of water and methanol at 25℃. The compounds were characterized by elemental analysis, IR, and X-ray diffraction single crystal structure analyses. Interactions of the complexes with calf thymus DNA (ctDNA) were investigated by UV-Vis spectra, luminescence spectra (including luminescence titrations, steady-state emission quenching by [Fe(CN)6]4-, DNA competitive binding with ethidium bromide (EB)), and viscosity measurements. The experimental results indicated that there were two interactions between the complexes and DNA, namely the electrostatic interaction and intercalation, with the binding constants of 1.82×105 L·mol-1 for 1 and 4.96×104 L·mol-1 for 2 in buffer of 50 mmol·L-1 NaCl and 5 mmol·L-1 Tris-HCl (pH 7.0). CCDC: 669692, 1; 674923, 2. |
