| 新型三联吡啶铜配合物的晶体结构及DNA切割活性(英文) |
| Crystal Structure and DNA Nuclease Activity of a Copper(Ⅱ) Complex of 4′-p-Tolyl-2,2′∶6,2″-Terpyridine |
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| 摘要: 本文合成了新型三联吡啶铜配合物[Cu(ttpy)(acetone)Cl]·(NO3)(H2O)3(ttpy=4′-p-tolyl-2，2′∶6，2″-terpyridine)，通过元素分析和X-射线单晶衍射进行结构表征。该配合物属三斜晶系，空间群为P1，晶胞参数为a=0.847 6(3) nm，b=1.265 0(5) nm，c=1.422 7(5) nm,α=111.017(7)°，β=92.174(7)°,γ=90.562(7)°,V=1.422 5(9) nm3，Z=2，Dc=1.309 Mg·m-3，μ(Mo Kα)=9.00 cm-1，F(000)=578，R1=0.063 3,wR=0.141 4。在配合物中，中心铜原子的配位环境为变形四方锥，并通过分子内和分子间的C-H…Cl和C-H…O氢键作用形成三维梯状结构。凝胶电泳结果表明，在pH=7.4，温度37°，以抗坏血酸为还原剂的条件下，该配合物对超螺旋pUC19 DNA表现出一定的切割活性。紫外-可见光谱结果显示，该配合物与四种核苷的反应活性顺序为：5′-GMP>5′-AMP>5′-TMP≈5′-CMP。 |
| 关键词: 三联吡啶铜配合物 晶体结构 DNA切割 |
| 基金项目: |
| Abstract: A novel copper(Ⅱ) terpyridine complex [Cu(ttpy)(acetone)Cl](NO3)(H2O)3 (ttpy=4′-p-tolyl-2,2′∶6,2″-terpyri-dine) had been synthesized and structurally characterized. The complex crystallized in the triclinic system, space group P1 with cell parameters: a=0.847 6(3) nm, b=1.265 0(5) nm, c=1.422 7(5) nm, α=111.017(7)°, β=92.174(7)°, γ=90.562(7)°, V=1.422 5(9) nm3, Z=2, Dc=1.309 Mg·m-3, μ(Mo Kα)=9.00 cm-1, F(000)=578, the final R1=0.063 3, wR2=0.141 4. The copper center was situated in a distorted square pyramidal (4+1) CuN3X2 coordination geometry with terpyridine acting as an equatorial tridentate ligand. The 3D ladder-like structure was connected by intra- and intermolecular C-H…Cl and C-H…O hydrogen bonds. The complex was able to cleave pUC19 DNA at micromole concentration in the presence of ascorbic acid. The reactivity of the complex towards four mononucleotides with the order: 5′-GMP>5′-AMP>5′-TMP≈5′-CMP, was determined by UV-Vis spectroscopy. CCDC: 625295. |
| Keywords: terpyridine-copper(Ⅱ) complex crystal structure DNA cleavage |
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| 姜 琴,施鹏飞,朱阳光,肖 楠,王大奇.新型三联吡啶铜配合物的晶体结构及DNA切割活性(英文)[J].无机化学学报,2009,25(4):589-595. |
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