| Abstract: Five new diethyltin N-[(2-oxyphenyl)methylene]glycinates, (CH3CH2)2Sn(2-O-3-X-5-YC6H2CH=NCH2 COO) (X, Y=H, H, 1; H, Cl, 2; H, Br, 3; Cl, Cl, 4; Br, Br, 5), have been prepared and characterized by elemental analysis, IR, 1H and 119Sn NMR spectra. The crystal structures of 1 and 4 have been determined. The crystal for 1 belongs to monoclinic space group P21, and the crystal for 4 belongs to triclinic space group P1. The two compounds have a 12-membered macrocyclic structure with a trimeric [Sn3O6C3] core. Each tin atom is six-coordinated in distorted [SnC2NO3] octahedron geometry. Bioassay results show that the compound 5 has in vitro anti-tumor activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7 and anti-bacterial activity against E. coli. CCDC: 729956, 1; 729957, 4. |
