| 一维链状三环己基锡羧酸酯的合成、晶体结构及生物活性 |
| The One-Dimensional Chain: Synthesis, Crystal Structure and Biological Activities of Tricyclohexyl Tin Carboxylates |
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| 摘要: 本文以含酯基刚性一元酸L1H(8-乙氧羰基-1-萘甲酸)和含羰基柔性一元酸L2H(4-羰基-4-苯基丁酸)作为多齿配体，分别与三环己基氢氧化锡发生自组装反应，获得了2个新型三环己基锡羧酸酯配合物[(C6H11)3SnL1] (1)和[(C6H11)3SnL2] (2)(C6H11为环己基)。采用元素分析、1H NMR、FTIR及晶体结构测定等手段对配合物1和2进行了结构表征，在2个新配合物中，锡原子均为六配位，构成以锡原子为中心的扭曲单加帽三角双锥构型，并且通过O→Sn分子间配位键形成了一维超分子链。初步研究了杀菌活性和抗癌活性。 |
| 关键词: 有机锡羧酸酯 三环己基氢氧化锡 8-乙氧羰基-1-萘甲酸 4-羰基-4-苯基丁酸 晶体结构 生物活性 |
| 基金项目: |
| Abstract: Two new supramolecular chains, namely [(R)3SnL1] (1) and [(R)3SnL2] (2) (where R=cyclohexyl, HL1=8-(ethoxycarbonyl)-1-naphthoic acid, HL2=4-cyclohexyl-4-oxobutanoic acid), were synthesized by the self-assemble reaction of R3SnOH with the corresponding acids in a suitable mole ratios respectively. Complexes 1 and 2 were structurally characterized by elemental analyses, FTIR spectroscopy, 1H NMR spectroscopy and single crystal X-ray diffraction analysis. The tin atom in complexes 1 and 2 adopts distorted monocapped trigonal bipyramidal geometry with six-coordinated, and exhibits a one-dimensional supramolecular chain through intermolecular O→ Sn interactions. The complexes 1 and 2 show antibiotic and anti-tumour activities in vitro experiments. CCDC: 796811, 1; 796812, 2. |
| Keywords: organotin carboxylate tricyclohexyltin hydroxide 8-(ethoxycarbonyl)-1-naphthoic acid,4-cyclohexyl-4-oxobutanoic acid crystal structure biological activity |
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| 摘要点击次数: 1886 |
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| 阿达玛,杜大峰,朱东升,许 林.一维链状三环己基锡羧酸酯的合成、晶体结构及生物活性[J].无机化学学报,2011,27(1):107-113. |
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