| 含吡啶的抗肿瘤转移NAMI-A衍生物的制备和水解机理动力学 |
| Preparation and Mechanism-Kinetics of Antimetastasis of NAMI-A Derivatives Containing Pyridine |
|
| 摘要: 目的 研究配体结构对NAMI-A衍生物水解机理、电化学性质的影响。方法 制备了trans-[RuCl4(DMSO)(3-MePy)][(3-MePy)H](3-MePy=3-甲基吡啶，化合物1)和trans-[RuCl4(DMSO)(4-MePy)][(4-MePy)H](4-MePy=4-甲基吡啶，化合物2)。用UV、NMR、CV法研究化合物1、化合物2的水解机理-动力学、溶液稳定性及电化学性质。结果 化合物1和化合物2与NAMI-A相似，在pH 7.40的缓冲液中发生脱氯水解反应(Ⅰ氯水解及Ⅱ氯水解)(分步反应)；在pH 5.00缓冲液中DMSO(二甲亚砜)及少量吡啶水解。测定各水解反应表观速率常数及半衰期、溶液稳定性及氧化还原电位。结论 化合物1、化合物2的Ⅰ氯、Ⅱ氯及DMSO水解反应机理与NAMI-A相似，而且各水解速率与NAMI-A相差不大，即用甲基吡啶取代咪唑环，对NAMI-A衍生物的Ⅰ氯、Ⅱ氯及DMSO水解反应速率影响较小。化合物在酸性溶液中的稳定性明显高于中性溶液。 |
| 关键词: 钌配合物 抗肿瘤转移 水解动力学 稳定性 |
| 基金项目: |
| Abstract: Objective To study the influence of ligand structure on the hydrolysis rate of anti-metastasis NAMI-A derivatives trans-[RuCl4(DMSO)(3-MePy)][(3-MePy)H] (3-MePy=3-methypyridine, Compd. 1) and trans-[RuCl4(DMSO)(4-MePy)][(4-MePy)H] (4-MePy=4-methypyridine, Compd. 2). Method Hydrolytic mechanism, kinetics, stability and electrochemistry of Compd. 1 and Compd. 2 were studied by UV-Vis, NMR and CV. Result The complexes undergo two well-separated steps of chloride hydrolysis at pH 7.40; while dimethyl sulfoxide (DMSO) hydrolyzed in pH 5.00 buffer solution. The Kobs and t1/2 for each reaction were determined. Conclusion Very similar to NAMI-A, the compounds loses 1st and 2nd chloride in two separated steps at pH 7.40; and loses DMSO in pH 5.00 buffer solution. The hydrolytic rate of the compounds including two chlorides and DMSO hydrolysis were similar to that of NAMI-A, which demonstrated that the influence of replacing imidazole by methyl pyridine on the hydrolysis rate of NAMI-A derivatives is not remarkable. The stability of the compounds in acidic solution is much more stable than that of in neutral solution. |
| Keywords: ruthenium complexes anti-metastasis hydrolytic kinetics stabilities |
| |
| 摘要点击次数: 1735 |
| 全文下载次数: 1704 |
| 梁曜华,毕 葳,梁国刚.含吡啶的抗肿瘤转移NAMI-A衍生物的制备和水解机理动力学[J].无机化学学报,2011,27(4):595-603. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: |
|
|
|
|
|
|
