| 3，4-二甲氧基苯乙酸邻菲咯啉锌配合物的合成及与DNA作用 |
| Synthesis and DNA-Binding of Zinc(Ⅱ) Complex with 3,4-Dimethoxyphenylacetic Acid and 1,10-Phenanthroline |
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| 摘要: 以3，4-二甲氧基苯乙酸(HDMPA，C10H12O4)为第一配体，邻菲咯啉(phen)为第二配体，Zn(OH)2为金属源合成了配合物[Zn(DMPA)2(phen)]·6H2O，并通过元素分析、红外光谱、摩尔电导对其进行表征及研究，用单晶X-射线衍射方法测定了配合物的晶体结构。配合物属于单斜晶系,空间群C2/c，晶胞参数：a=2.047 29(4) nm，b=1.006 19(2) nm，c=1.812 94(4) nm，β=112.986 0(10)°，晶胞体积：V=3.438 06(12) nm3，晶胞内结构基元数Z=4，式量Mr=744.05。在配合物中，中心金属锌(Ⅱ)离子与2个二甲氧基苯乙酸根离子中的2个氧原子和1个邻菲咯啉中的2个氮原子配位，配位数为4。用溴化乙锭荧光探针法测试了配合物与DNA的作用，结果表明标题配合物具有较强的插入作用。 |
| 关键词: 锌(Ⅱ)配合物 3，4-二甲氧基苯乙酸 晶体结构 DNA |
| 基金项目: |
| Abstract: A zinc(Ⅱ) complex [Zn(DMPA)2(phen)]·6H2O was synthesized from 3,4-dimethoxyphenylacetic acid (HDMPa=C10H12O4), 1,10-phenanthroline(phen) and Zn(OH)2, and characterized by elemental analysis, infrared radiation, molar conductance. Its crystal structure was determined by single crystal X-ray diffraction method. The complex, C32H42N2O14Zn, crystallizes in the monoclinic system, space group C2/c, with cell parameters: a=2.047 29(4) nm, b=1.006 19(2) nm, c=1.812 94(4) nm, β=112.986 0(10)°, cell volume: V=3.438 06(12) nm3, number of molecules inside the cell: Z=4, relative molecular mass: Mr=744.05. The crystal structure shows the zinc(Ⅱ) atom is four-coordinated by two oxygen atoms from two DMPA- anions and two nitrogen atoms of 1,10-phenanthroline molecule. The interaction between complex and DNA was studied by EtBr fluoescent probe, and the results show that the complex interact with DNA by intercalative mode. CCDC: 793918. |
| Keywords: zinc(Ⅱ) complex 3,4-dimethoxyphenylacetic acid crystal structure DNA |
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| 郭航鸣,赵国良,吴小勇,沈金杯.3，4-二甲氧基苯乙酸邻菲咯啉锌配合物的合成及与DNA作用[J].无机化学学报,2011,27(5):855-859. |
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