| 乳酸钴配合物与牛血清蛋白相互作用的研究 |
| Syntheses of a Series of Lactato Cobalt Complexes and Their Interaction with Bovine Serum Albumin |
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| 摘要: 合成和表征了系列乳酸钴配合物，测定二水二乳酸钴配合物的结构，配合物中乳酸的羟基和羧基配位键平均键长分别为0.206 0(2) nm和0.206 8(2) nm。当[Co(Hlact)2(H2O)2] (2)或[Co(Hlact)2(phen)]·2H2O (4)配合物与牛血清白蛋白(BSA=Bovine Serum Albumin)相互作用后，红外光谱显示乳酸或邻菲咯啉的特征吸收消失，钴离子与BSA出现新的配位，初步推定乳酸或邻菲咯啉配体被BSA中的强配体所取代。 |
| 关键词: 钴离子 乳酸 邻菲咯啉 牛血清白蛋白 |
| 基金项目: |
| Abstract: A series of lactate cobalt complexes are synthesized and characterized by spectral and structural analyses, including [Co(Hlact)2(H2O)2]·H2O (1), [Co(Hlact)2(H2O)2] (2), [Co(Hlact)(phen)(H2O)2]Cl (3) and [Co(Hlact)2(phen)]·2H2O (4) (Lactic acid=H2lact; 1,10-phenanthroline=phen). Their interactions with Bovine Serum Albumin (BSA) are investigated with infra-red spectra. CCDC: 819899. |
| Keywords: cobalt lactic acid phenanthroline bovine serum albumin (BSA) |
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| 林海彬,汪庆祥,周朝晖.乳酸钴配合物与牛血清蛋白相互作用的研究[J].无机化学学报,2011,27(7):1239-1244. |
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