| 具有肿瘤荧光成像性能的核壳纳米过氧化氢酶模拟物(英文) |
| Tumor-Imaging Core-Shell Nano-Models for Catalase |
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| 摘要: 运用微波法在硅核壳荧光材料的表面修饰了2-(二吡啶甲胺基)丙酸的锰配合物，获得具有荧光性能的锰-硅核壳纳米结构复合物，运用IR，UV，TEM等方法表征了纳米复合物的结构。H2O2岐化实验显示锰-硅核壳纳米复合物具有较好的过氧化氢酶模拟特性， 是一种新的纳米过氧化氢酶模拟物。体外细胞荧光成像研究表明2-(二吡啶甲胺基)丙酸修饰的纳米球不能进入肿瘤细胞内，而锰-硅核壳纳米复合物能进入肿瘤细胞内，具备良好的肿瘤靶向性，显著提高肿瘤荧光成像效果，可作为新型的肿瘤成像剂。 |
| 关键词: 核壳纳米球 纳米复合物 成像 肿瘤 |
| 基金项目: |
| Abstract: Microwave synthesis approach has been developed for preparing Mn-silica core-shell nano-complexes with fluorescent imaging by assembling the Mn(Ⅱ) complexes of bis(2-pyridylmethyl)amino-2-propionic acid (Adpa) on the surface of silica core-shell nanoparticles. IR, UV, TEM were used to characterize the structure of nano-complexes. The results of H2O2 disproportionation show that Mn-silica core-shell nano-complexes have good analog characteristics of catalase as a new kind of nano-models for catalase. Cell fluorescence image in vitro indicates that these Adpa modified nanoparticles locate outside of tumor cells, in contrast, Mn-silica core-shell nano-complexes could enter tumor cells which enables simultaneous tumor-targeting and good fluorescent imaging as a new tumor imaging agent. |
| Keywords: core-shell nanosphere nano-complex imaging, cancer |
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| 杨 霞,陈秋云,宋京宝.具有肿瘤荧光成像性能的核壳纳米过氧化氢酶模拟物(英文)[J].无机化学学报,2012,28(1):164-170. |
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