| 大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究 |
| Synthesis and Release Behavior of Emodin Intercalated Mg-Al Hydrotalcite-Like Compounds |
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| 摘要: 以Mg-Al型层状双金属氢氧化物(Mg-Al-LDHs)为载体，将大黄素分子通过二次组装法成功插入其层间，得到大黄素/Mg-Al-LDHs纳米杂化物。XRD结果显示，Mg-Al-LDHs粒子层间距由0.48 nm增大到3.35 nm。差热曲线(DTA曲线)分析结果表明，该纳米杂化物分子中大黄素的分解温度比纯大黄素的分解温度高50 ℃。分别在pH 4.8和pH 7.5的缓冲溶液中测定了大黄素/LDHs的缓释性能，结果表明大黄素/LDHs的药品释放速率明显低于二者的物理混合物，并探讨了释放机理。 |
| 关键词: 层状双金属氢氧化物(LDHs) 大黄素 插层 缓释 |
| 基金项目: |
| Abstract: In this paper, emodins were successfully intercalated into the gallery of Mg-Al hydrotalcite-like compounds (LDHs), to obtain nanohybrids. The results of X-ray powder diffraction (XRD) showed that the interlayer distance of Mg-Al-LDHs was increased from 0.48 nm to 3.35 nm. The DTA results suggested that the discomposition temperature of the nanohybrids increased by 50 ℃ in comparison with that of emodin. The determination results of the drug release indicated that the drug release rate from the emodin/LDHs nanohybrids was much slower than that from the corresponding physical mixture at either pH 4.8 or pH 7.5. The release mechanism was discussed. |
| Keywords: layered double hydroxides(LDHs) emodin intercalation controlled release |
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| 戴肖南,王其鹏.大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究[J].无机化学学报,2012,28(3):560-564. |
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