| 酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究(英文) |
| Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones |
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| 摘要: 本文合成了2个新的结构类似的酰腙氧钒(Ⅴ)配合物，[VOL(OCH3)(CH3OH)](L=L1=2-氯-N′-(5-氯-2-羟基苯亚甲基)苯甲酰肼(1)；L=L2=2-氯-N′-(2-羟基-3-甲氧基苯亚甲基)苯甲酰肼(2))，并通过物理化学方法和单晶X-射线衍射表征了它们的结构。在每个配合物中，V原子都采取八面体配位构型，利用配体L中的3个给体原子和1个甲氧配体的氧原子定义其赤道面，利用1个酮氧原子和1个甲醇氧原子占据其2个轴向位置。本文还研究了这2个配合物对幽门螺旋杆菌脲酶的抑制活性。在浓度为100 μmol·L-1时，配合物1和2对脲酶的抑制率分别为(82.0%±2.8%)和(28.2%±1.7%)。此外，还做了配合物和幽门螺旋杆菌脲酶的分子对接研究。 |
| 关键词: 酰腙 钒氧(Ⅴ)配合物 晶体结构 脲酶 抑制剂 |
| 基金项目: |
| Abstract: Two new structural similar oxovanadium(Ⅴ) complexes with the formulae [VOL(OCH3)(CH3OH)] (L=L1=2-chloro-N′-(5-chloro-2-hydroxybenzylidene)benzohydrazide (1); L=L2=2-chloro-N′-(2-hydroxy-3-methoxybenzyli-dene)benzohydrazide (2)), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The V atom in each complex is in an octahedral coordination, with the three donor atoms of L and one methanolato O atom defining the equatorial plane, and with one oxo O atom and one methanol O atom occupying the axial positions. The complexes were evaluated for their urease inhibitory activities. The percent inhibition of the complexes 1 and 2 at the concentration of 100 μmol·L-1 on Helicobacter pylori urease are 82.0%±2.8% and 28.2%±1.7%. The molecular docking study of the complexes with the urease was performed. CCDC: 844338, 1; and 844339, 2. |
| Keywords: hydrazone oxovanadium(Ⅴ) complex crystal structure urease inhibitor |
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| 张吉才,李海华,献冬梅,张 梅,甄苗苗,赵 月,由忠录.酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究(英文)[J].无机化学学报,2012,28(9):1959-1966. |
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