| SCN-桥联的铜配合物：抗肿瘤活性及对肿瘤细胞耗氧的影响(英文) |
| SCN-bridged Cu(Ⅱ) Complexes: Anticancer Activity and Effect on Attenuation of O2 Consumption in HepG-2 Cells |
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| 摘要: 合成和表征了一种新的N-苯基二吡啶甲基胺 (phdpa)铜配合物[(phdpa)Cu(SCN)](ClO4)。X-衍射晶体结构数据显示配合物中铜原子与配体phdpa中3个N原子、SCN-中S原子和邻近分子中SCN- 中N 原子配位，形成扭曲八面体结构。生物活性数据显示该铜配合物抑制HepG-2细胞的生长，半数抑制率为10.4 μmol·L-1。进一步机理研究数据显示这种SCN-桥联的铜配合物能诱导HepG-2细胞核的分裂，降低其耗氧量和ROS的含量，这表明该铜配合物是一种能影响HepG-2细胞氧代谢的多功能配合物。 |
| 关键词: 铜配合物 抗肿瘤 ROS 耗氧量 晶体结构 |
| 基金项目: |
| Abstract: A new copper(Ⅱ) complex of N-benzyl di(2-pyridylmethyl)amine (phdpa) was synthesized and characterized. X-ray crystal structure shows that the copper atom in [(phdpa)Cu(SCN)](ClO4) is coordinated with a phdpa and a SCN- forming a coordinated polymer. In vitro essay results show that this copper(Ⅱ) complex exhibits good inhibition on the proliferation of HepG-2 cells with IC50 of 10.4 μmol·L-1. In addition, [(phdpa)Cu(SCN)] (ClO4) can induce the obvious nucleus fragmentation of HepG-2 cells, decrease the O2 consumption and reactive oxygen species (ROS) level in HepG-2 cells, indicating that this SCN-bridged copper(Ⅱ) complex is a multi-functional copper(Ⅱ) complex. CCDC: 840495. |
| Keywords: copper(Ⅱ) complex antitumor ROS O2 consumption crystal structure |
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| 马正平,陈秋云,封 如,陈甜甜.SCN-桥联的铜配合物：抗肿瘤活性及对肿瘤细胞耗氧的影响(英文)[J].无机化学学报,2012,28(11):2395-2400. |
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