| 含2,4-二氨基-6-(2′-吡嗪)-均三嗪及甘氨酸的铜(Ⅱ)配合物的合成、晶体结构及与DNA作用 | |
| Synthesis, Crystal Structure and DNA-Binding Properties of Copper(Ⅱ) Complex with 6-(Pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine and Glycinate | |
| 摘要: 以2,4-二氨基-6-(2′-吡嗪)-均三嗪(PZTA)及甘氨酸为配体与高氯酸铜作用合成了配合物[Cu(H2O)(Gly)(PZTA)]ClO4(Gly=甘氨酸根).通过元素分析、测定摩尔电导率、红外光谱和紫外可见光谱进行表征,并用单晶X-射线衍射方法测定了该配合物的晶体结构.配合物晶体属于单斜晶系,空间群C2/c,晶胞参数：a=2.189 6(3) nm,b=1.308 3(2) nm,c=1.465 4 (4) nm,β=131.467(3)°,晶胞体积：V=3.145 6(9) nm3,晶胞内结构基元数：Z=8,Dc=1.876 g·cm-3,最后的残差因子：R1=0.037 4,wR2=0.100 9.应用紫外光谱、溴化乙锭荧光探针及粘度测定等方法研究了配合物与DNA的作用.结果表明,主题配合物以部分插入方式与DNA作用. | |
| 关键词: 铜(Ⅱ)配合物 2,4-二氨基-6-(2′-吡嗪)-均三嗪 甘氨酸 晶体结构 脱氧核糖核酸 | |
| 基金项目: 广东省自然科学基金(No.10151064201000016)及华南农业大学211工程重点项目(No.2009B010100001)资助项目. | |
| Abstract: The copper(Ⅱ) complex [Cu(H2O)(Gly)(PZTA)]ClO4 (Gly=glycinate) was prepared by the reaction of 6-(pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine (PZTA) and glycine (Gly) with copper(Ⅱ) perchlorate, and characterized by elemental analysis, infrared radiation, UV-Vis, and molar conductance. Its crystal structure was determined by single crystal X-ray diffraction method. The complex crystallizes in the monoclinic system, space group C2/c, with cell parameters: a=2.189 6(3) nm, b=1.308 3(2) nm, c=1.465 4(4) nm, β=131.467(3)°, cell volume: V=3.145 6(9) nm3, number of molecules inside the cell: Z=8, final R indices (I>2σ(I)): R1=0.037 4, wR2=0.100 9. The interaction of the complex to DNA was studied by UV spectroscopy, EtBr fluoescent probe and viscosity measurement. The results indicate that the complex could interact with DNA by partial intercalative mode. CCDC: 848150. | |
| Keywords: copper(Ⅱ) complex 6-(pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine glycine crystal structure DNA | |
| 投稿时间：2012-03-11 修订日期：2012-07-08 | |
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| 张雪梅,区志镔,陈实,熊亚红,周晓华,刘海峰,乐学义.含2,4-二氨基-6-(2′-吡嗪)-均三嗪及甘氨酸的铜(Ⅱ)配合物的合成、晶体结构及与DNA作用[J].无机化学学报,2012,28(12):2667-@. | |
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