| 由蒽醌衍生的二价和三价过渡金属偶氮配合物及其致突变－畸变作用 |
| Bivalent and Trivalent Transition Metal Complexes of Azo Compounds Derived from Anthraquinone and Their Mutagenic-Teratogenic Effects |
| 作者 | 单位 | E-mail | | Yildiz E | Department of Chemistry, Arts and Science Faculty, Cukurova University, Balcali 01330, Adana, Turkiye | eeyildiz@cu.edu.tr | | Karadeniz B | Department of Chemistry, Arts and Science Faculty, Cukurova University, Balcali 01330, Adana, Turkiye | | | Yildiz A M | Department of Biology, Arts and Science Faculty, Cukurova University, Balcali 01330, Adana, Turkiye | | | Rencuzogullari E | Department of Biology, Arts and Science Faculty, Cukurova University, Balcali 01330, Adana, Turkiye | |
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| 摘要: 制备了4-(5'-氨基萘-3'-磺酸)偶氮-(2″-N-(4''',6'''-二氯-S-三嗪)苯-5″-(β-羟乙基砜硫酸酯)-2-甲基蒽醌(2a),4-(2'-氨基苯磺酸)偶氮-(2″-N-(4''',6'''-二氯-S-三嗪)-3″-苯磺酸)-2-甲基蒽醌,4-(5'-氨基萘-3'-磺酸)偶氮-(2″-N-(4''',6'''-二氯-S-三嗪)苯-5″-(β-羟乙基砜硫酸酯)-2-甲基蒽醌和4-(p-(β-羟乙基砜硫酸酯)偶氮-(2″-N-(4''',6'''-二氯-S-三嗪)萘-5″-磺酸)-2-甲基蒽醌的FeⅢ,CoⅡ金属配合物,并在安姆/沙门氏菌/微粒体致突变试验(Ames/Salmonella/Microsome Test)和大鼠胚胎中测定其致突变-畸变作用。不管是否使用代谢赋活剂S9mix,2a-Fe和2a-Co对TA98 and TA100菌株均无致突变－畸变作用。 |
| 关键词: 蒽醌 偶氮 金属配合物 致突变作用 致畸变作用 |
| 基金项目: TUBITAK, TBAG 107T409资助项目(Supported by TUBITAK, TBAG 107T409）。 |
| Abstract: 4-(5'-aminonaphtalene-3'-sulfonic acid)azo-(2″-N-(4''', 6'''-dichloro-S-triazine) benzene-5″-(β-sulfatoethyl sulfonyl)-2-methyl anthraquinone (2a), 4-(2'-aminobenzenesulfonic acid)azo-(2″-N-(4''', 6'''-dichloro-S-triazine)-3″-benzensulfonic acid)-2-methyl anthraquinone, 4-(5'-aminonaphtalene-3'-sulfonic acid)azo-(2″-N-(4''', 6'''-dichloro-S-triazine)benzen-5″-(β-sulfatoethyl sulfonyl)-2-methyl anthraquinone and 4-(p-(β-sulfatoethyl sulfonyl) azo-(2″-N-(4''', 6'''-dichloro-S-triazine) naphtalene-5″sulfonic acid)-2-methyl anthraquinone with FeⅢ,CoⅡ metal complexes were prepared and used for determination of mutagenic and teratogenic effects in Ames/Salmonella/Microsome Test and in embryos of rats. 2a-Fe and 2a-Co were not mutagenic for both TA98 and TA100 strains with and without metabolic activator S9mix. |
| Keywords: anthraquinone azo metal complex mutagenicity teratogenicity |
| 投稿时间：2012-05-25 修订日期：2012-09-06 |
| 摘要点击次数: 2125 |
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| Yildiz E,Karadeniz B,Yildiz A M,Rencuzogullari E.由蒽醌衍生的二价和三价过渡金属偶氮配合物及其致突变－畸变作用[J].无机化学学报,2013,29(3):595-604. |
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