| 氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物：合成和生物学应用 |
| Ternary Transition Metal Complexes of Nitrilotriacetic Acid and Valine or Leucine：Synthesis and Biological Applications |
| 作者 | 单位 | E-mail | | Mostafa M H Khalil | Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt.(埃及) | | | Eglal R Souaya | Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt.(埃及) | | | Eman H Ismail | Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt.(埃及)
Chemistry Department, Faculty of Science, Taibah University, Al-Madina Al-Munawarah, B.O: 344., Kingdom of Saudi Arabia(沙特阿拉伯王国) | dr_science_7@hotmail.com | | Eman Rabie | Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt.(埃及) | |
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| 摘要: 以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明,三元配合物可在金属(M):氨三乙酸(HNTA):缬氨酸(valine)或亮氨酸(leucine)＝1:1:1时制得,其分子结构为[M(HNTA)(valine)(H2O)2]·1.5H2O and[M(HNTA)(leucine)(H2O)2]·1.5H2O(其中M=Ni(Ⅱ) or Cu(Ⅱ))和H2[Zn(NTA)(valine)(H2O)]H2O。标题三元过渡金属配合物为八面体对称构型。同时研究了该三元配合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,黄曲霉菌(菌株从开罗大学理学院微分析中心获得)的抗菌活性。根据推荐的知名方法用标准的抗菌和抗真菌剂进行体外测试(in vitro)以评估我们的新制备的配合物对细菌和真菌物种的生长抑制活性。 |
| 关键词: 缬氨酸 亮氨酸 三元配合物 生物学应用 |
| 基金项目: |
| Abstract: Ternary complexes of Ni(Ⅱ), Cu(Ⅱ), and Zn(Ⅱ) with nitrilotriacetic acid HNTA2- as a primary ligand and valine or leucine as a secondary ligand were synthesized in slightly acidic medium. The new complexes were characterized by elemental analysis, FTIR, UV-Vis spectroscopy, thermal analysis, magnetic measurements and mass spectroscopy. The results indicate that the ternary complexes are isolated in M:HNTA:valine(or leucine) ratio of 1:1:1, and the molecular structures are suggested to be[M(HNTA)(valine)(H2O)2]·1.5H2O and[M(HNTA) (leucine)(H2O)2]·1.5H2O, where M=Ni(Ⅱ) or Cu(Ⅱ) and H2[Zn(NTA)(valine)(H2O)] H2O. The suggested geometry of our ternary metal complexes is an octahedral symmetry. The antimicrobial activities of prepared complexes against Escherichia coli, Staphylococcus aureus, Candida albicans and Aspergillus flavus (isolates from Microanalytical Center, Faculty of Science, Cairo University) were also investigated. The complexes were tested in vitro to assess growth inhibitory activity against the bacterial and fungal species with standard antibacterial and antifungal agents according to the recommended known method. |
| Keywords: valine leucine ternary complexes biological applications |
| 投稿时间：2013-02-16 修订日期：2013-05-28 |
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| Mostafa M H Khalil,Eglal R Souaya,Eman H Ismail,Eman Rabie.氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物：合成和生物学应用[J].无机化学学报,2013,29(9):1969-1978. |
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