| 苯磺酰苯丙氨酸构筑的一维链状钙(Ⅱ)配位聚合物的合成、结构表征和抗肿瘤活性 |
| Synthesis, Crystal Structure and Antitumor Activity of Ca(Ⅱ) Coordination Polymer Constructed by N-Benzenesulphonyl-L-phenylalanine |
| 作者 | 单位 | E-mail | | 台夕市 | College of Chemistry and Chemical Engineering, Weifang University, Weifang, Shandong 261061, China | taixs@wfu.edu.cn, taixishi@lzu.edu.cn | | 赵文华 | Department of Chemistry, Qinghai Normal University, Xining 810008, China | | | 李法辉 | College of Chemistry and Chemical Engineering, Weifang University, Weifang, Shandong 261061, China | |
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| 摘要: 在95%乙醇溶剂中,通过高氯酸钙、苯磺酰苯丙氨酸和NaOH反应,合成了一个新型的一维链状钙配位聚合物。对其进行了元素分析和红外光谱分析表征,并用X-射线单晶衍射测定了它的单晶结构。结果表明:在配合物分子中,每个钙原子分别与配体中羧酸根的4个氧原子、配位水中的2个氧原子以及配位乙醇分子中的1个氧原子配位,形成了畸变的五角双锥构型。配合物分子通过羧酸根的桥联作用形成了一维链状配位聚合物结构。初步研究了配合物对肝癌、肺腺癌、白血病和结肠癌的抗肿瘤活性。 |
| 关键词: 苯磺酰苯丙氨酸 Ca(Ⅱ)配位聚合物 合成 结构表征 抗肿瘤活性 |
| 基金项目: 国家自然科学基金(No.21171132;No.20671073),山东省优秀中青年科学家奖励基金(No.2010BSA07004),潍坊市鸢都学者岗位团队项目和潍坊市科技发展计划资助项目。 |
| Abstract: Colourless crystals of 1Dcoordination polymer, [Ca(L)2(H2O)2(CH3CH2OH)]n (L=N-benzenesulphonyl-L-phenylalanine), were obtained by the reaction of calcium perchlorate and N-benzenesulphonyl-L-phenylalanine in the 95% CH3CH2OH solution, and characterized by elemental analysis, IRand X-ray single crystal diffraction analysis. The single-crystal X-ray analysis of the title complex reveals that each Ca(Ⅱ) atom is seven-coordinated in a distorted pentagonal bipyramid coordination environment by seven oxygen atoms from the N-benzenesulphonyl-L-phenylalanine ligand, the coordinated water molecule and the coordinated CH3CH2OH molecule, respectively. The molecular structure is 1D coordination polymer by the interaction of bridged carboxylato groups. The antitumor activity against SMMC-7721, A549, WiDr and P388 cancer cells of the Ca(Ⅱ) complex also was investigated. CCDC: 890991. |
| Keywords: N-benzenesulphonyl-L-phenylalanine Ca(Ⅱ) coordination polymer synthesis crystal structure antitumor activity |
| 投稿时间：2012-11-14 修订日期：2013-05-22 |
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| 台夕市,赵文华,李法辉.苯磺酰苯丙氨酸构筑的一维链状钙(Ⅱ)配位聚合物的合成、结构表征和抗肿瘤活性[J].无机化学学报,2013,29(10):2200-2204. |
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