| 基于Schiff碱及咪唑类配体的镍（Ⅱ）配合物的合成、结构及其抑菌活性研究 |
| Synthesis, Crystal Structure and Antibacterial Activity of Schiff Base Ni(Ⅱ) Complexes Containing Schiff Base and Imidazole |
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| 摘要: 以三齿席夫碱配体H2L{1-苯基-3-[（2-羟基苯）亚胺]-1-丁酮}和单齿N-杂环[咪唑（Himdz），2-甲基咪唑（Mimdz）]与Ni（OAc）2·4H2O进行配位反应，得到2个配合物[Ni（L）（Himdz）]（1），[Ni（L）（Mimdz）]（2）。并用元素分析，FTIR和X-射线单晶衍射进行了表征。在固体状态，配合物1和2都属于单斜晶系，P21/c空间群，分子间通过C-H…π相互作用形成二聚体，二聚体中的每个分子通过N-H…O氢键向空间扩展成一维锯齿链状结构。初步研究了配体和配合物的体外抑菌活性，结果表明，配合物1和2具有一定的抑菌活性。 |
| 关键词: Ni（Ⅱ）配合物 晶体结构 氢键 抑菌活性 |
| 基金项目: 国家自然科学基金（No.21061003）；贵州省联合基金（黔科合LG字[2012]016）；贵阳医学院青年基金资助项目。 |
| Abstract: The two nickel (Ⅱ) complexes [Ni(L)(Himdz)](1)、[Ni(L)(Mimdz)](2) were synthesized from the reaction of tridentate Schiff base (1-phenyl-3-[(2-hydroxyphenyl)imino]-1-butanone) (H2L) and monodentate N-heterocycles [imidazole (Himdz), 2-methylimidazole (Mimdz)] with Ni(OAc)2·4H2O and characterized by elemental analysis, IR, 1H NMR spectroscopy. An X-ray structure determination of the complexes has been completed. In the solid state, both [Ni(L)(Himdz)] (1), [Ni(L)(Mimdz)] (2) crystallize in P21/c space groups, and exist as dimers due to intermolecular C-H…π interactions. Each of the dimeric molecules forms a one-dimensional zigzag chain via intermolecular N-H…O hydrogen bonds involving the heterocycle N-H group, respectively. The antibacterial activities of the ligand and complexes were tested against seven kinds of bacteria. The results show that the complexes 1 and 2 possess inhibiting effects. |
| Keywords: Ni(Ⅱ)Complex crystal structure hydrogen bonds antibactenal activity |
| 投稿时间：2013-05-17 修订日期：2013-10-31 |
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| 张奇龙,冯广卫,王丽,王正,朱必学.基于Schiff碱及咪唑类配体的镍（Ⅱ）配合物的合成、结构及其抑菌活性研究[J].无机化学学报,2014,30(5):1025-1030. |
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