| 两个三环己基锡芳香羧酸酯的合成、结构、热稳定性及体外抗癌活性研究 | |
| Synthesis, Crystal Structure, Thermal Stability and Anti-tumor Activity in vitro of Two Tricyclohexyltin Aromatic Carboxylates | |
| 摘要: 甲醇中三环己基氢氧化锡分别与呋喃-2-甲酸、2，4，6-三甲基苯甲酸反应，合成了2个三环己基锡芳香羧酸酯Cy3SnO2CC4H3O(1)和Cy3SnO2CC6H2Me3(2)(Cy为环己基)。通过IR、1H和13C NMR、元素分析及X-射线单晶衍射表征结构。1和2均属单斜晶系，配合物1空间群P21，晶体学参数：a=0.823 04(2) nm，b=1.111 19(3) nm，c=1.283 90(3) nm，β=101.090(2)°，Z=2，V=1.152 27(5) nm3，Dc=1.381 g·cm-3，μ(Mo Kα)=1.127 mm-1，F(000)=496，R1=0.052 9，wR2=0.138 7。配合物2空间群P21/c，晶体学参数：a=0.999 62(2) nm，b=1.415 97(2) nm，c=1.973 59(3) nm，β=94.042 0(10)°，Z=4，V=2.786 53(8) nm3，Dc=1.266 g·cm-3，μ(Mo Kα)=0.937 mm-1，F(000)=1 112，R1=0.0540，wR2=0.161 9。配合物(1)和(2)的中心锡原子均为畸变四面体构型。通过分子间氢键作用，配合物(1)形成二维网状结构。试验表明，配合物1和2具有良好的热稳定性，对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460增殖均有较强的抑制作用。 | |
| 关键词: 三环己基锡芳香羧酸酯 合成 晶体结构 抗癌活性 | |
| 基金项目: 湖南省自然科学基金(No.13JJ3112)，湖南省科技计划(No.2013TZ2025)，湖南省高校创新平台开放基金(No.13K105)和教育厅一般项目(No.12C0537)，衡阳市科技计划(No.2011KG56，2012KJ30)，衡阳师范学院协同创新中心培育项目(No.12XT02)及衡阳师范学院青年骨干教师培养计划(2012)基金资助。 | |
| Abstract: Two tricyclohexyltin aromatic carboxylates Cy3SnO2CC4H3O(1) and Cy3SnO2CC6H2Me3(2) were synthesized by the reactions of 2-furancarboxylic acid and 2,4,6-trimethylbenzoic acid with tricyclohexyltin hydroxide, respectively. The two complexes were characterized by IR, 1H and 13C NMR, elemental analysis and X-ray crystal diffraction. The crystal of complex 1 belongs to monoclinic system, space group P21, a=0.823 04(2) nm, b=1.111 19(3) nm, c=1.283 90(3) nm, β=101.090(2) °, Z=2, V=1.152 27(5) nm3, Dc=1.381 g·cm-3, μ(Mo Kα)=1.127 mm-1, F(000)=496, R1=0.052 9, wR2=0.138 7. The crystal of complex 2 belongs to monoclinic system, space group P21/c, a=0.999 62(2) nm, b=1.415 97(2) nm, c=1.973 59(3) nm, β=94.042 0(10)°, Z=4, V=2.786 53(8) nm3, Dc=1.266 g·cm-3, μ(Mo Kα)=0.937 mm-1, F(000)=1 112, R1=0.054 0, wR2=0.161 9. The tin atoms of complex 1 and 2 are distorted tetrahedral configuration, a 2D structure of complex 1 is formed by intermolecular hydrogen bonds. The tests showed the two complexes displayed good thermal stability and strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460. CCDC: 832549, 1; 809068, 2. | |
| Keywords: tricyclohexyltin aromatic carboxylate synthesis crystal structure anti-tumor activity | |
| 投稿时间：2013-08-24 修订日期：2013-11-11 | |
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| 庾江喜,冯泳兰,邝代治,张复兴,蒋伍玖,朱小明.两个三环己基锡芳香羧酸酯的合成、结构、热稳定性及体外抗癌活性研究[J].无机化学学报,2014,30(6):1267-1272. | |
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