单核Ru(Ⅲ)-edta类配合物的合成、结构及性质研究
Synthesis, Structures and Characterization of Two Mononuclear Ru(Ⅲ)-edta Complexes
作者单位E-mail
况微微 淮北师范大学化学与材料科学学院, 淮北 235000  
杨培培 淮北师范大学化学与材料科学学院, 淮北 235000 hbnuypp@163.com 
摘要: 采用K[Ru(Hedta)Cl]·1.5H2O(edta为乙二胺四乙酸根)与含氮杂环配体5-(4-吡啶)四唑(4-ptz)或2,5-吡啶二甲酸(2,5-Pydc)反应, 设计合成了2个单核[Ru(Hedta)(4-ptz)]·4H2O(1)和[Ru(Hedta)(2,5-Pydc)]·3H2O(2)配合物.晶体结构解析表明配合物1属于单斜晶系C2/c空间群, 晶胞参数为a=2.348 06(15) nm,b=1.301 23(8) nm,c=1.493 08(9) nm,β=101.075 0(10)°;配合物2属于单斜晶系I2/a空间群, 晶胞参数为a=3.249 4(7) nm,b=0.966 23(19) nm,c=1.434 1(3) nm,β=93.88(3)°.对2个配合物分别进行了IR及UV-Vis的表征, 并通过电子吸收光谱和荧光淬灭光谱研究了配合物与DNA的作用, 实验结果表明这2个钌配合物通过插入方式与DNA作用.
关键词: Ru(Ⅲ)配合物  晶体结构  光谱表征  与DNA相互作用
基金项目: 国家自然科学基金(No.21101068)、安徽省自然科学基金(No.1308085MB16)资助项目.
Abstract: Two ruthenium(Ⅲ) complexes containing ethylenediaminetetraacetate (edta), [Ru(Hedta)(4-ptz)]·4H2O (1) and [Ru(Hedta)(2,5-Pydc)]·3H2O (2), have been synthesized by the K[Ru(Hedta)Cl]·1.5H2O reacting with 5-(4-Pyridyl)tetrazole (4-ptz) or 2,5-Pyridinedicarboxylic acid (2,5-Pydc) in water solution. Complex 1 crystallizes in monoclinic system, space group C2/c with a=2.348 06(15) nm, b=1.301 23(8) nm, c=1.493 08(9) nm, β=101.075 0(10)°. Complex 2 crystallizes in monoclinic system, space group I2/a with a=3.249 4(7) nm, b=0.966 23(19) nm, c=1.434 1(3) nm, β=93.88(3)°. The products were characterized by IR and UV-Vis. Their DNA-binding activities were investigated using electronic absorption spectroscopic methods and fluorescence quenching; the experimental results show that these two ruthenium complexes may bind to CT-DNA through intercalation modes. CCDC: 604187, 1; 603213, 2.
Keywords: Ru(Ⅲ) complex  crystal structure  spectral characterization  interaction with DNA
投稿时间:2013-12-05 修订日期:2014-09-18
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况微微,杨培培.单核Ru(Ⅲ)-edta类配合物的合成、结构及性质研究[J].无机化学学报,2014,30(12):2719-2725.
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